SOX2在口腔鳞癌中的表达及其与EMT的相关性

doi:10.13701/j.cnki.kqyxyj.2017.11.019

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (11): 1209-1212.DOI: 10.13701/j.cnki.kqyxyj.2017.11.019

SOX2在口腔鳞癌中的表达及其与EMT的相关性

徐飞, 王姗, 孟琰, 施磊, 强冬霞, 赵尔杨^*

哈尔滨医科大学第一临床医学院·口腔医学院口腔病理科黑龙江哈尔滨 150001

收稿日期:2017-06-13 出版日期:2017-11-20 发布日期:2017-11-29
通讯作者: 赵尔杨,电话:0451—85553979
作者简介:徐飞(1987~ ),男,哈尔滨人,硕士,医师,主要从事口腔病理学研究工作。

Expression of SOX2 in OSCC and Its Correlation with EMT

XU Fei, WANG Shan, MENG Yan, SHI Lei, QIANG Dong-xia, ZHAO Er-yang^*

Department of Oral Pathology, College of Stomatology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Received:2017-06-13 Online:2017-11-20 Published:2017-11-29

摘要/Abstract

摘要： 目的:探讨SOX2在口腔鳞状细胞癌(OSCC)中的表达水平及其与E-cad和Vim的相互关系。方法:采用免疫组化SP法检测50例OSCC与13例正常口腔上皮中SOX2、E-cad和Vim的表达信号。采用SPSS19.0软件包进行计数资料方差分析和spearman等级相关分析。结果:在正常口腔上皮中,SOX2不表达;在OSCC中,SOX2的表达随着组织分型的降低而升高(P<0.05)。在正常口腔上皮中,E-cad强阳性表达;在OSCC中,E-cad的表达随着组织分型的降低而降低(P<0.05)。在正常口腔上皮中Vim不表达;在OSCC中,Vim的表达随着组织分型的降低而升高(P<0.05)。在OSCC中,SOX2和E-cad的表达呈负性相关(P<0.05);SOX2和Vim的表达呈正性相关(P<0.05);E-cad和Vim的表达呈负性相关(P<0.05)。结论:SOX2表达水平与OSCC的分化程度密切相关,同时与上皮间充质转化标记物E-cad和Vim分别存在负性与正性相关。

关键词: SOX2, 上皮间充质转化, 鳞状细胞癌

Abstract: Objective: To investigate the expression of SOX2 in OSCC and to evaluate its relationship with the expression of E-cad and Vim. Methods: The expressions of SOX2, E-cad, and Vim in 50 patients with oral squamous cell carcinoma and 13 specimens of oral pericancerous epithelium were detected by immunohistochemical staining method. Statistical analysis was performed with SPSS 19.0 software package. Results: The expression of SOX2 in oral epithelium was negative and the expression of SOX2 increased with the decrease of tissue type in OSCC (P<0.05). The expression of E-cad in oral epithelium was positive and the expression of E-cad decreased with the decrease of tissue type in OSCC (P<0.05). The expression of Vim in oral epithelium was negative and the expression of Vim increased with the decrease of tissue type in OSCC (P<0.05). In OSCC, the expressions of SOX2 and E-cad were negatively correlated (P<0.05), the expressions of SOX2 and Vim were positively correlated (P<0.05), and the expressions of E-cad and Vim were negatively correlated (P<0.05). Conclusion: Various expressions of SOX2 were found in different histological grade while the expression enhanced with the degrading of the differentiation degree, and there were negative correlations between SOX2 and epithelial mesenchymal transformation marker E-cad, and positive correlations between SOX2 and the marker Vim.

Key words: SOX2, Epithelial-mesenchymal transition, Squamous cell carcinoma

中图分类号:

R739.8

徐飞, 王姗, 孟琰, 施磊, 强冬霞, 赵尔杨. SOX2在口腔鳞癌中的表达及其与EMT的相关性[J]. 口腔医学研究, 2017, 33(11): 1209-1212.

XU Fei, WANG Shan, MENG Yan, SHI Lei, QIANG Dong-xia, ZHAO Er-yang. Expression of SOX2 in OSCC and Its Correlation with EMT[J]. Journal of Oral Science Research, 2017, 33(11): 1209-1212.

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SOX2在口腔鳞癌中的表达及其与EMT的相关性

Expression of SOX2 in OSCC and Its Correlation with EMT

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