牙龈卟啉单胞菌fimA分型与相关疾病的研究

doi:10.13701/j.cnki.kqyxyj.2018.12.005

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (12): 1281-1283.DOI: 10.13701/j.cnki.kqyxyj.2018.12.005

牙龈卟啉单胞菌fimA分型与相关疾病的研究

杜留熠,吕慧欣,王鹞,周延民^*

吉林大学口腔医院种植中心吉林长春 130021

收稿日期:2018-01-25 出版日期:2018-12-28 发布日期:2018-12-27
通讯作者: 周延民,E-mail: Zhouym62@163.com
作者简介:杜留熠(1994~ ),女,河北人,硕士,主要研究方向为口腔种植学。
基金资助:
国家自然科学基金(编号:81570983)吉林省科技厅国际合作处项目(编号:20180414030GH)吉林大学研究生创新基金资助项目(编号:2017014)

Research on fimA Genotyping and Related Diseases of Porphyromonas Gingivalis.

DU Liu-yi, LV Hui-xin, WANG Yao, ZHOU Yan-min^*

Department of Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China.

Received:2018-01-25 Online:2018-12-28 Published:2018-12-27

摘要/Abstract

摘要： 牙龈卟啉单胞菌与牙周组织感染、糖尿病、冠状动脉粥样硬化性心脏病(简称冠心病)等疾病的发生发展密切相关。菌毛是牙龈卟啉单胞菌重要的毒力因子,可以协助牙龈卟啉单胞菌黏附和入侵宿主细胞。根据FimA蛋白编码基因fimA核苷酸序列的不同可将其分为Ⅰ、Ⅰb、Ⅱ、Ⅲ、Ⅳ和Ⅴ等6种基因型,不同fimA基因型菌株的致病力和与疾病的相关性有一定差异。本文重点综述近年来不同fimA基因型牙龈卟啉单胞菌菌毛与相关疾病的研究进展。

关键词: 牙龈卟啉单胞菌, 菌毛, fimA基因, 牙周炎, 动脉粥样硬化

Abstract: Porphyromonas gingivalis (P.gingivalis) is involved in the occurrence and development of various diseases including periodontal tissue infections, diabetes, coronary heart disease, and etc.Fimbriae is an important virulence factor of P.gingivalis and can assist it to adhere and invade host cells.P.gingivalis strains are classified into six types based on divergent nucleotide sequences of the fimA gene (types Ⅰ, Ⅰb, Ⅱ, Ⅲ, Ⅳ, and Ⅴ).The pathogenicity of P.gingivalis strains with different fimA genotypes was different.This review focuses on the recent progress in the study of different fimA genotypes and related diseases of P.gingivalis fimbriae.

Key words: Porphyromonas gingivalis, Fimbriae, fimA genotyping, Periodontitis, Atherosclerosis

杜留熠,吕慧欣,王鹞,周延民. 牙龈卟啉单胞菌fimA分型与相关疾病的研究[J]. 口腔医学研究, 2018, 34(12): 1281-1283.

DU Liu-yi, LV Hui-xin, WANG Yao, ZHOU Yan-min. Research on fimA Genotyping and Related Diseases of Porphyromonas Gingivalis.[J]. Journal of Oral Science Research, 2018, 34(12): 1281-1283.

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牙龈卟啉单胞菌fimA分型与相关疾病的研究

Research on fimA Genotyping and Related Diseases of Porphyromonas Gingivalis.

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