内皮间充质转化在肿瘤中的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.11.004

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (11): 1023-1025.DOI: 10.13701/j.cnki.kqyxyj.2019.11.004

内皮间充质转化在肿瘤中的研究进展

刘欣辰^1,2, 孙宏晨^1*

1. 吉林省牙发育及颌骨重塑与再生重点实验室吉林长春 130021;
2. 吉林大学口腔医院牙体牙髓科吉林长春 130021

收稿日期:2018-12-22 出版日期:2019-11-28 发布日期:2019-11-21
通讯作者: 孙宏晨,E-mail: hcsun@mail.jlu.edu.cn
作者简介:刘欣辰(1995~ ),女,内蒙古包头人,硕士在读,主要从事肿瘤微环境的研究。
基金资助:
国家自然科学基金(编号:81320108011) 吉林省科技厅自然科学基金项目(编号:20170101093JC) 吉林省省级产业创新专项资金项目(编号:2016C044-3)

Research Progress of Endothelial Mesenchymal Transition in Tumors

LIU Xinchen^1,2, SUN Hongchen^1*

1. Key Laboratory of Dental Development and Jaw Remodeling and Regeneration in Jilin Province, Changchun 130021, China;
2. Department of Endodontics, School of Stomatology, Jilin University, Changchun 130021, China

Received:2018-12-22 Online:2019-11-28 Published:2019-11-21

摘要/Abstract

摘要： 内皮间充质转化(endothelial-mesenchymal transition,EndMT)指内皮细胞(endothelial cells,ECs)在受到炎症因子刺激后获得间充质细胞样表型。EndMT不仅参与胚胎发育和器官纤维化,而且还对肿瘤的发生发展产生了重要的影响。本文就近几年来EndMT对肿瘤的影响以及相关机制作一综述,以期为肿瘤治疗提供新的思路。

关键词: 内皮间充质转化, 肿瘤, 肿瘤相关成纤维细胞

Abstract: Endothelial-mesenchymal transition (EndMT) means that endothelial cells acquire mesenchymal-like phenotype after stimulated by inflammatory factors. EndMT is not only involved in embryonic development and organ fibrosis, but also has an important impact on the occurrence and development of tumors. This article reviews the effects and mechanisms of EndMT on tumor in recent years in order to provide new ideas and targets for tumor treatment.

Key words: endothelial-mesenchymal transition, cancer, cancer-associated fibroblasts

刘欣辰, 孙宏晨. 内皮间充质转化在肿瘤中的研究进展[J]. 口腔医学研究, 2019, 35(11): 1023-1025.

LIU Xinchen, SUN Hongchen. Research Progress of Endothelial Mesenchymal Transition in Tumors[J]. Journal of Oral Science Research, 2019, 35(11): 1023-1025.

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内皮间充质转化在肿瘤中的研究进展

Research Progress of Endothelial Mesenchymal Transition in Tumors

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