口腔鳞状细胞癌中CASZ1的表达及临床意义

doi:10.13701/j.cnki.kqyxyj.2022.01.007

口腔医学研究 ›› 2022, Vol. 38 ›› Issue (1): 30-33.DOI: 10.13701/j.cnki.kqyxyj.2022.01.007

口腔鳞状细胞癌中CASZ1的表达及临床意义

齐元莉¹, 闫红娟¹, 祖木热提古丽·阿不来提¹, 张超杰², 赵举红³, 徐江^1*

1.石河子大学医学院第一附属医院口腔科新疆石河子 832008;
2.武汉儿童医院口腔科湖北武汉 430014;
3.哈密市中心医院口腔科新疆哈密 839000

收稿日期:2021-08-19 出版日期:2022-01-28 发布日期:2022-01-21
通讯作者: * 徐江,E-mail:1437759520@qq.com
作者简介:齐元莉(1994~ ),女,安徽淮北人,硕士在读,研究方向:口腔全科。
基金资助:
国家自然科学基金地区项目(编号:81560442)

Expression and Clinical Significance of CASZ1 in Oral Squamous Cell Carcinoma

QI Yuanli¹, YAN Hongjuan¹, Zumu reti-guli·ABLANTI¹, ZHANG Chaojie², ZHAO Juhong³, XU Jiang^1*

1. Department of Stomatology,The First Affiliated Hospital,Shihezi UniversitySchool of Medicine, Shihezi 832008, China;
2. Department of Stomatology,Children's Hospital of Wuhan, Wuhan 430014, China;
3. Department of Stomatology,Hami Central Hospital, Hami 839000, China

Received:2021-08-19 Online:2022-01-28 Published:2022-01-21

摘要/Abstract

摘要： 目的:探讨CASZ1在口腔鳞状细胞癌(OSCC)中的表达及临床意义。方法:通过TCGA数据库探讨CASZ1 mRNA在OSCC中的表达情况,采用免疫组织化学方法检测OSCC组织及癌旁组织中CASZ1蛋白表达水平并分析CASZ1蛋白的表达与OSCC患者临床病理特征以及预后的关系。结果:TCGA数据库结果显示,CASZ1 mRNA在OSCC中表达水平下调,差异有统计学意义(P＜0.001)。OSCC组织中CASZ1蛋白低表达率[65.6%(80/122)]明显高于癌旁组织中CASZ1蛋白的低表达率[34.9%(22/63)],差异有统计学意义(P＜0.001),且CASZ1蛋白低表达与T分期有关(P<0.05)。Kaplan-Meier分析结果显示,CASZ1蛋白低表达组患者总生存率明显低于高表达组(P<0.05)。多因素COX回归模型分析结果显示,CASZ1蛋白低表达以及T分期是影响患者预后的独立因素(P<0.05)。结论:OSCC中CASZ1表达水平明显降低,且CASZ1蛋白低表达与OSCC患者生存期短有关。

关键词: 预后, 口腔鳞状细胞癌, 转录因子, CASZ1

Abstract: Objective: To investigate the expression and clinical significance of CASZ1 in oral squamous cell carcinoma (OSCC). Methods: The expression of CASZ1 mRNA in OSCC was discussed through TCGA database. Immunohistochemical method was used to detect the expression of CASZ1 protein in OSCC and adjacent normal tissues, and to analyze the relationship between the expression of CASZ1 protein and the clinicopathological features and prognosis of OSCC patients. Results: The results of TCGA database showed that the expression level of CASZ1 mRNA was down regulated in OSCC (P<0.001). The low expression rate of CASZ1 protein in OSCC tissues (65.6%, 80/122) was significantly higher than that in normal tissues adjacent to cancer (34.9%, 22/63, P<0.001). The low expression of CASZ1 protein was related to the T stage (P<0.05). Kaplan-Meier analysis showed that the overall survival rate of patients in the low expression group of CASZ1 protein was significantly lower than that in the high expression group (P<0.05). The results of multivariate COX regression model analysis showed that the low expression of CASZ1 protein and the T stage were independent factors affecting the prognosis of patients (P<0.05). Conclusion: The expression level of CASZ1 in OSCC is significantly reduced, and the low expression of CASZ1 protein is related to the short survival time of OSCC patients, which may be a new potential marker for poor prognosis in OSCC patients.

Key words: prognosis, oral squamous carcinoma, transcription factor, CASZ1

齐元莉, 闫红娟, 祖木热提古丽·阿不来提, 张超杰, 赵举红, 徐江. 口腔鳞状细胞癌中CASZ1的表达及临床意义[J]. 口腔医学研究, 2022, 38(1): 30-33.

QI Yuanli, YAN Hongjuan, Zumu reti-guli·ABLANTI, ZHANG Chaojie, ZHAO Juhong, XU Jiang. Expression and Clinical Significance of CASZ1 in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2022, 38(1): 30-33.

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口腔鳞状细胞癌中CASZ1的表达及临床意义

Expression and Clinical Significance of CASZ1 in Oral Squamous Cell Carcinoma

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