磷酸二酯酶抑制剂在口腔领域的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.07.002

摘要/Abstract

摘要： 磷酸二酯酶(phosphodiesteras,PDEs)可以水解细胞内第二信使环磷酸腺苷和环磷酸鸟苷,以调控机体相关生理活动,参与炎症、骨吸收等过程。PDEs抑制剂是一种以抑制PDEs活性为主的药物,本文拟对PDEs抑制剂在辅助治疗口腔炎症疾病、拔牙创口愈合、皮瓣移植、颌骨骨折愈合以及牙齿移动等影响的相关研究进行综述,以期为口腔领域相关治疗提供参考。

关键词: 磷酸二酯酶抑制剂, 炎症, 骨改建

Abstract: Phosphodiesterases (PDEs) can hydrolyze the second messenger cyclic adenosine monophosphate and cyclic guanosine monophosphate in cells to regulate relevant physiological activities of the body and participate in inflammation, bone absorption, and other processes. PDEs inhibitor is a drug that mainly inhibits the activity of phosphodiesterase. This article intends to review the related research and development of PDEs inhibitors in the auxiliary treatment of oral inflammatory diseases, wound healing after tooth extraction, skin flap transplantation, jaw fracture healing, and tooth movement, so as to provide reference for the related treatment in stomatology.

Key words: phosphodiesterase inhibitor, inflammation, bone remodeling

苏琦, 周志迎. 磷酸二酯酶抑制剂在口腔领域的研究进展[J]. 口腔医学研究, 2023, 39(7): 574-577.

SU Qi, ZHOU Zhiying. Research Progress of Phosphodiesterase Inhibitors in Stomatology[J]. Journal of Oral Science Research, 2023, 39(7): 574-577.

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