具核梭杆菌影响动脉粥样硬化的分子机制

doi:10.13701/j.cnki.kqyxyj.2022.04.003

摘要/Abstract

摘要： 动脉粥样硬化是冠状动脉粥样硬化性心脏病、脑卒中等心血管疾病重要的发病和死亡原因。现已证实牙周病与动脉粥样硬化是独立相关的。具核梭杆菌是牙周炎龈下菌斑中常见致病菌,在牙周组织处于炎症状态时,具核梭杆菌可通过受损的毛细血管进入血液循环,而后粘附侵入内皮细胞,破坏内皮完整性,导致内皮功能障碍。同时,具核梭杆菌及其热休克蛋白可导致脂质代谢紊乱,并激活促炎因子,增强炎症反应,最终导致动脉粥样斑块的形成。本文就具核梭杆菌对动脉粥样硬化影响的可能机制进行探讨。

关键词: 动脉粥样硬化, 具核梭杆菌, FadA, GroEL, 炎症反应, 脂质代谢

Abstract: Atherosclerosis is an important morbidity and mortality cause of cardiovascular diseases such as coronary heart disease and stroke. It has been confirmed that periodontal disease is independently related to atherosclerosis. Fusobacterium nucleatum is a common pathogenic bacterium in the subgingival plaque of periodontitis. When periodontal tissue is in a state of inflammation, Fusobacterium nucleatum can enter the blood circulation through damaged capillaries, and then adhere to endothelial cells, destroying endothelial integrity and causing endothelial dysfunction. At the same time, Fusobacterium nucleatum and its heat shock protein can activate pro-inflammatory factors, enhance inflammatory response, lead to disorder of lipid metabolism, and eventually lead to the formation of atherosclerotic plaque. Therefore, this article reviews the possible molecular mechanisms of the interaction between Fusobacterium nucleatum and atherosclerosis.

Key words: atherosclerosis, Fusobacterium nucleatum, FadA, GroEL, inflammation, dyslipidemia

蒋端, 申道南. 具核梭杆菌影响动脉粥样硬化的分子机制[J]. 口腔医学研究, 2022, 38(4): 308-311.

JIANG Duan, SHEN Daonan. Research on Molecular Mechanism of Effect of Fusobacterium Nucleatum on Atherosclerosis[J]. Journal of Oral Science Research, 2022, 38(4): 308-311.

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