Sox基因在口腔鳞状细胞癌中作用及机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2022.04.004

摘要/Abstract

摘要： Sox基因家族是广泛存在于人体组织内的一类编码基因,其编码的Sox蛋白作为重要的转录调控因子,不仅参与调节人体生长发育的整个进程,还参与介导了包括口腔鳞状细胞癌在内的多系统肿瘤的发生发展。本文从Sox基因的上下游相互作用因子、相关信号通路及临床诊治潜能等方面综述了其在口腔鳞状细胞癌中的作用,以期为研究者提供新的研究方向和思路。

关键词: Sox, 口腔鳞状细胞癌, 上皮-间充质转化

Abstract: Sox gene family is a kind of coding genes widely existed in human tissues. As an important transcription regulator, Sox protein not only participates in the whole process of animal growth and development, but also participates in the tumorigenesis and development of multiple system tumors including oral squamous cell carcinoma. In this paper, we reviewed the function of Sox gene in oral squamous cell cancer from the aspects of upstream and downstream interaction factors, related signal pathways, and clinical diagnosis and treatment potential, in order to provide new research direction and ideas for researchers.

Key words: Sox, oral squamous cell carcinoma, epithelial to mesenchymal transition

彭艳霜, 刘英. Sox基因在口腔鳞状细胞癌中作用及机制的研究进展[J]. 口腔医学研究, 2022, 38(4): 312-315.

PENG Yanshuang, LIU Ying. Review on the Role and Mechanism of Sox Gene in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2022, 38(4): 312-315.

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