Abstract: Oral diseases have always been existed throughout the evolution process of human being. The history and development of stomatology, which is an important part of human civilization, recorded the relentless efforts and endeavors of mankind to fight against oral diseases. This article used three words-Replacement, Reconstruction and Regeneration, which have milestone importance in the development of stomatolgy, to describe the history of stomatology. In short, the past of stomatology was centered by replacement, the present is characterized by reconstruction, and the future is symbolized by regeneration. The three "Rs", which represent the history and prospect of stomatology, will provide fundamental understanding for education, clinical care and research in stomatology.