口腔医学研究

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (12): 1289-1292.DOI: 10.13701/j.cnki.kqyxyj.2018.12.007

• 口腔肿瘤学研究 • 上一篇    下一篇

颌骨成釉细胞癌10例临床分析

邹海啸1,2,吴丽芬2,3,李辰2,3,赵怡芳2,3,孙艳芳2,3*   

  1. 1. 南昌大学第二附属医院口腔科 江西 南昌 330006;
    2. 口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室 湖北 武汉 430079;
    3. 武汉大学口腔医院口腔颌面头颈肿瘤外科 湖北 武汉 430079
  • 收稿日期:2018-05-01 出版日期:2018-12-28 发布日期:2018-12-27
  • 通讯作者: 孙艳芳,E-mail:sunyanfang@whu.edu.cn
  • 作者简介:邹海啸(1985~ ),男,湖北武汉人,主治医师,主要从事口腔颌面部肿瘤的基础研究和诊疗。
  • 基金资助:
    国家自然科学基金(编号: 81500379)

Clinical Characteristics of Ameloblastic Carcinoma of the Jaw: 10 Cases Report

ZOU Hai-xiao1,2, WU Li-fen2,3, LI Chen2,3, ZHAO Yi-fang2,3, SUN Yan-fang2,3*   

  1. 1. Department of Stomatology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China;
    2. The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China;
    3. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
  • Received:2018-05-01 Online:2018-12-28 Published:2018-12-27

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摘要： 目的: 报道10例颌骨成釉细胞癌的临床特点、治疗和预后。方法: 回顾性分析2012~2016年间就诊的10例颌骨成釉细胞癌患者的临床资料。结果: 本组病例中,男性7例,女性3例,男女比例为2.3∶1,发病年龄17~85岁,中位年龄52岁,原发型2例,继发型8例,2例发生于上颌骨,8例发生于下颌骨,其中3例见于下颌骨左侧。3例患者曾有手术治疗史,6例病变累及下颌骨磨牙、升支区。患者就诊的主要原因为颌面部的肿胀、疼痛,所有患者均接受手术治疗,同期行颈淋巴清扫术者4例,术后未发现颈部淋巴结有转移癌形成;同期行植骨术者4例,其中腓骨肌皮瓣1例,髂骨肌瓣3例。随访1.5~4年,2例患者失访,4例患者出现复发,其中2例患者曾有保守治疗手术史。结论: 成釉细胞癌为罕见的颌骨恶性肿瘤,临床表现常不典型,提高对该病认识,有利于为患者选择适宜的治疗方案,降低复发率。

关键词: 成釉细胞癌, 颌骨, 诊断, 治疗

Abstract: Objective: To report the clinical characteristics and prognosis of 10 cases of ameloblastic carcinoma.Methods: The clinical data of 10 cases of ameloblastic carcinoma of the jaw were retrospectively analyzed.Results: There were 7 male and 3 female patients included in this study, with a male-to-female ratio of 2.3:1.Their ages ranged from 17 to 85 years (median, 52 years).Two cases occurred de novo, whereas 8 patients presented with carcinoma ex-ameloblastoma.Three patient had surgery treatment history.The posterior mandible was involved in 6 cases.Most patients attended to our department with chief complain of swelling and pain.Surgery was scheduled for all patients.There were 4 patients received cervical neck dissection at the same time.No cervical lymph node metastasis was found postoperation.Four cases received bone grafting in the same period.During the follow-up period of 1.5-4 years, 2 patients were lost, recurrence occurred in 4 patients, of which 2 patients had conservative operation history.Conclusion: Ameloblastic carcinoma is a rare malignant tumor, and the clinical manifestations are often atypical.It is important to improve the understanding of the disease for choosing considerable treatment.

Key words: Ameloblastic carcinoma, Jaws, Diagnosis, Treatment