3D打印鹿角粉/聚乙烯醇支架与纳米级羟基磷灰石/聚乙烯醇支架的性能比较

doi:10.13701/j.cnki.kqyxyj.2018.09.022

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (9): 1011-1015.DOI: 10.13701/j.cnki.kqyxyj.2018.09.022

3D打印鹿角粉/聚乙烯醇支架与纳米级羟基磷灰石/聚乙烯醇支架的性能比较

赵小琦,丁刘闯,韩祥祯,李俊杰,周琦琪,宋艳艳,何惠宇^*

新疆医科大学第一附属医院口腔修复科新疆乌鲁木齐 830054

收稿日期:2018-02-08 出版日期:2018-09-28 发布日期:2018-09-25
通讯作者: 何惠宇,E-mail:hehuiyu01@126.com
作者简介:赵小琦(1992~ ),女,新疆库尔勒人,硕士在读,主要研究口腔修复学及组织工程研究。
基金资助:
国家自然科学基金(编号:81660177)

Performance Comparison of 3D Printed Antler Powder/Polyvinyl Alcohol Scaffolds and Nano-scale Hydroxyapatite/Polyvinyl Alcohol Scaffolds.

ZHAO Xiao-qi, DING Liu-chuang, HAN Xiang-zhen, LI Jun-jie, ZHOU Qi-qi, SONG Yan-yan, HE Hui-yu^*

Department of Prosthodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.

Received:2018-02-08 Online:2018-09-28 Published:2018-09-25

摘要/Abstract

摘要： 目的: 构建一种新型支架材料(鹿角粉/PVA支架),并与n-HA/PVA支架对比,通过检测其理化、生物性能,评价并探讨其作为骨组织工程支架的可行性。方法: 利用3D打印技术,分别制备出鹿角粉/PVA支架、n-HA/PVA支架,进行孔隙率、孔径、吸水率、压缩力学性能及生物相容性的检测。结果: 两组支架孔隙率比较无差别,鹿角粉/PVA孔径大于n-HA/PVA支架(P=0.004);在不同时间点上,n-HA/PVA支架的吸水率大于鹿角粉/PVA支架,但鹿角粉/PVA支架持续吸水的时间较长;两组支架的抗压缩性能无差别(P=0.243),但韧性较n-HA/PVA支架好;鹿角粉/PVA支架细胞相容性优于n-HA/PVA支架。结论: 鹿角粉/PVA支架具有良好的机械力学性能及细胞相容性,可作为异种骨支架材料研究的新方向。

关键词: 3D打印, 鹿角粉, 纳米级羟基磷灰石, 聚乙烯醇, 支架材料

Abstract: Objective: A new scaffold material (antler powder/PVA scaffold) was constructed, and compared with n-HA/PVA scaffold. By testing its physicochemical and biological properties, its feasibility as a scaffold for bone tissue engineering was evaluated and explored. Methods: The antler powder/PVA scaffolds and n-HA/PVA scaffolds were respectively prepared by 3D printing technology to test the porosity, pore size, water absorption, compressive mechanical properties, and biocompatibility. Results: There was no difference in the porosity of two groups, and the pore sizes of antler powder/PVA scaffold were larger than those of n-HA/PVA scaffolds (P=0.004). At different time points, the water absorption of the n-HA/PVA scaffolds was greater than that of the antler powder/PVA scaffolds. However, the antler powder/PVA scaffolds had longer duration of water absorption. The compression resistance of two groups was not different (P=0.243). However, the toughness of antler power/PVA scaffold was better than that of n-HA/PVA scaffolds, and the cell compatibility was the same. Conclusion: Antler powder/PVA scaffolds have good mechanical properties and cell compatibilities, which can be used as a new direction to study the xenogeneic scaffolds.

Key words: 3D printing, Antler powder, Nano-hydroxyapatite, Polyvinyl alcohol, Scaffold material

赵小琦,丁刘闯,韩祥祯,李俊杰,周琦琪,宋艳艳,何惠宇. 3D打印鹿角粉/聚乙烯醇支架与纳米级羟基磷灰石/聚乙烯醇支架的性能比较[J]. 口腔医学研究, 2018, 34(9): 1011-1015.

ZHAO Xiao-qi, DING Liu-chuang, HAN Xiang-zhen, LI Jun-jie, ZHOU Qi-qi, SONG Yan-yan, HE Hui-yu. Performance Comparison of 3D Printed Antler Powder/Polyvinyl Alcohol Scaffolds and Nano-scale Hydroxyapatite/Polyvinyl Alcohol Scaffolds.[J]. Journal of Oral Science Research, 2018, 34(9): 1011-1015.

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3D打印鹿角粉/聚乙烯醇支架与纳米级羟基磷灰石/聚乙烯醇支架的性能比较

Performance Comparison of 3D Printed Antler Powder/Polyvinyl Alcohol Scaffolds and Nano-scale Hydroxyapatite/Polyvinyl Alcohol Scaffolds.

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