[1] Saekel R. Oral health data from China and their relevance for Germany [J]. Prophylaxe Impuls, 2010, 14: 6. [2] Shang XH, Li DL, Huang Y, et al. Prevalence of dental caries among preschool children in Shanghe County of Shandong Province and relevant prevention and treatment strategies [J]. Chin Med J (Engl), 2008, 121(22): 2246-2249. [3] 冯希平.中国居民口腔健康状况——第四次中国口腔健康流行病学调查报告[A].2018年中华口腔医学会第十八次口腔预防医学学术年会论文汇编[C]. 2018. [4] 曹茜茜,樊牮,孙晶晶,等.重组亚单位和合成肽防龋疫苗的免疫效能[J].口腔医学研究,2014,30(3):193-196. [5] Matsumoto-Nakano M, Fujita K, Ooshima T. Comparison of glucan-binding proteins in cariogenicity of Streptococcus mutans [J]. Oral Microbiol Immunol 2007, 22(1): 30-35. [6] Rather SA, Sharma SC, Mahmood A. Antibodies generated against dextransucrase exhibit potential anticariostatic properties in Streptococcus mutans [J]. Appl Microbiol Biotechnol, 2020, 104(4):1761-1772. [7] Takashima Y, Fujita K, Ardin AC, et al. Characterization of the dextran-binding domain in the glucan-binding protein C of Streptococcus mutans [J]. J Appl Microbiol, 2015, 119(4):1148-1157. [8] Lynch DJ, Michalek SM, Zhu M, et al. Cariogenicity of Streptococcus mutans glucan-binding protein deletion mutants [J]. Oral Health Dent Manag, 2013, 12(4):191-199. [9] 潘勇,齐延新,李晓媛,等.基于高分子的疫苗递送系统构建和应用[J].应用化学,2021,38(5):582-591. [10] 韩琪,柴巧学,曲云鹏,等.变异链球菌葡聚糖结合蛋白A葡聚糖结合区真核表达质粒的构建及其在哺乳动物细胞中的表达[J].牙体牙髓牙周病学杂志,2010,20(6):310-313. [11] 亓鹏.温敏型生物降解水凝胶载体防龋基因疫苗不同途径免疫 SD大鼠的实验研究[D].遵义:遵义医学院,2011. [12] Gambhir RS, Singh S, Singh G, et al. Vaccine against dental caries-an urgent need [J]. J Vaccines Vaccination, 2012, 3: 136. [13] Yan H.Salivary IgA enhancement strategy for development of a nasal-spray anti-caries mucosal vaccine [J]. Sci China Life Sci, 2013, 56(5):406-413. [14] 叶倩琳,李祯,曹茜茜,等.自组装纳米粒子防龋疫苗的免疫效能[J].口腔医学研究,2017,33(10):1023-1026. [15] Bai G, Tian Y, Wu J, et al. Construction of a fusion anti-caries DNA vaccine in transgenic tomato plants for PAcA gene and cholera toxin B subunit [J]. Biotechnol Appl Biochem, 2019, 66(6):924-929. [16] 关薇薇,顾瑜,管晓燕,等.转基因番茄防龋疫苗中外源目的基因鉴定及表达检测[J].中国组织工程研究,2022,26(2):171-175. [17] Hoces D, Arnoldini M, Diard M, et al. Growing, evolving and sticking in a flowing environment: understanding IgA interactions with bacteria in the gut [J]. Immunology, 2020, 159 (1):52-62. [18] Kim SH, Lee KY, Jang YS. Mucosal immune system and M cell-targeting strategies for oral mucosal vaccination [J]. Immune Netw, 2012, 12(5):165-175. [19] Azizi A, Kumar A, Diaz-Mitoma F, et al. Enhancing oral vaccine potency by targeting intestinal M cells [J]. PLoS Pathogens, 2010, 6(11): e1001147. [20] Vela Ramirez JE, Sharpe LA, Peppas NA. Current state and challenges in developing oral vaccines[J]. Adv Drug Deliv Rev, 2017, 114:116-131. [21] Huang J, Jia R, Shen H, et al. Oral delivery of a DNA vaccine expressing the PrM and E genes: a promising vaccine strategy against flavivirus in ducks [J]. Sci Rep, 2018,8(1):12360. [22] Zhang Y, Li M, Du G, et al. Advancedoral vaccine delivery strategies for improving the immunity [J]. Adv Drug Deliv Rev, 2021, 177:113928. [23] Huang P, Wang X, Liang X, et al. Nano-, micro-, and macroscale drug delivery systems for cancer immunotherapy [J]. Acta Biomater, 2019, 85:1-26. [24] Mitsui R, Matsukawa M, Nakagawa K, et al. Efficient cell transplantation combining injectable hydrogels with control release of growth factors [J]. Regen Ther, 2021, 25(18):372-383. [25] 管晓燕,李敏,刘建国,等.温敏型生物降解水凝胶载体防龋基因疫苗 pVAX1-spap/A 经不同途径免疫新西兰大白兔的实验研究[J].口腔医学研究,2014,30(10):934-938. |