线粒体与骨髓间充质干细胞成骨分化关系的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.01.002

摘要/Abstract

摘要： 骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSC)因其在体内外的高度分裂分化潜能和易获得性而被广泛应用于骨组织工程学与再生医学。然而,难以控制移植BMSC的分化方向是干细胞治疗中的一大难题。线粒体是绝大部分真核细胞必备的细胞器,BMSC分化过程伴随线粒体的动态变化,包括线粒体形态、分布、数目、动力学以及线粒体代谢转变等方面。同时,线粒体在决定BMSC分化命运中不可或缺。因此,探究线粒体与BMSC成骨分化命运的关系对骨相关疾病的治疗有巨大价值。本文综述了线粒体在BMSC成骨分化中的研究进展,阐述了再生医学和骨修复中BMSC线粒体靶向治疗的潜在策略,期望拓宽骨组织工程学和再生医学的治疗选择。

关键词: 骨髓间充质干细胞, 成骨, 线粒体, 骨组织工程

Abstract: Bone marrow mesenchymal stem cells (BMSCs) are widely used in bone tissue engineering and regenerative medicine due to their high potential for differentiation and availability. However, difficult to control the differentiation direction of transplanted BMSCs is a major problem in stem cell therapy. Mitochondria are essential organelles of most eukaryotic cells. The differentiation of BMSCs is accompanied by dynamic changes of mitochondria, including morphology, distribution, number, dynamics, and metabolic transformation. Meanwhile, studies show that mitochondria are indispensable in determining BMSCs differentiation fate. Therefore, exploring the relationship between mitochondria and osteogenic differentiation fate of BMSCs is significant for the treatment of bone related diseases. In this review, we report recent advances on the function of mitochondria in BMSCs osteogenic differentiation and the potential strategies for mitochondrial targeted therapy in regenerative medicine and bone repair, promising to broaden therapeutic options of bone tissue engineering and regenerative medicine.

Key words: bone marrow mesenchymal stem cells, osteogenesis, mitochondrial, bone engineering

李晨, 甘雪琦. 线粒体与骨髓间充质干细胞成骨分化关系的研究进展[J]. 口腔医学研究, 2023, 39(1): 11-14.

LI Chen, GAN Xueqi. Research Advances in Relationship between Mitochondria and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells[J]. Journal of Oral Science Research, 2023, 39(1): 11-14.

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