Hippo-YAP信号通路影响牙周组织炎症及再生的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.01.004

摘要/Abstract

摘要： 牙周炎是一种常见的慢性炎症性疾病,可导致牙周支持组织进行性破坏,在控制炎症的基础上尽可能争取一定程度的牙周组织再生是牙周炎的治疗目标。Hippo信号通路是一条高度保守的信号通路,在机械传导、炎症、干细胞功能调控、细胞增殖和分化,以及肿瘤的发生、发展等过程中都起着重要的作用。本文综述了Hippo-YAP信号通路在牙周组织炎症及牙周组织再生中发挥的作用,以期为牙周炎的治疗提供新的思路。

关键词: 牙周炎, Hippo-YAP信号通路, 牙周组织再生

Abstract: Periodontitis is a common chronic inflammatory disease, which leads to the progressive destruction of periodontal supporting tissues. On basis of controlling inflammation, striving for a certain degree of periodontal tissue regeneration is the treatment goal of periodontitis. Hippo signaling pathway is a highly conserved signaling pathway, which plays a vital role in mechanical conduction, inflammation, function regulation of stem cells, cell proliferation and differentiation, and tumor occurrence and development. This paper reviews the role of Hippo signaling pathway in periodontal inflammation and periodontal tissue regeneration, in order to provide new inspiration for the treatment of periodontitis.

Key words: periodontitis, Hippo-YAP signaling pathway, periodontal tissue regeneration

赵慧伟, 刘树泰. Hippo-YAP信号通路影响牙周组织炎症及再生的研究进展[J]. 口腔医学研究, 2023, 39(1): 20-23.

ZHAO Huiwei, LIU Shutai. Research Progress of Hippo-YAP Signaling Pathway on Inflammation and Regeneration of Periodontal Tissue[J]. Journal of Oral Science Research, 2023, 39(1): 20-23.

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