肠道菌群与寻常型天疱疮关系的研究进展

doi:10.13701/j.cnki.kqyxyj.2026.01.003

口腔医学研究 ›› 2026, Vol. 42 ›› Issue (1): 12-16.DOI: 10.13701/j.cnki.kqyxyj.2026.01.003

肠道菌群与寻常型天疱疮关系的研究进展

赵璨¹, 石晶^1,2*

1.山西医科大学口腔医学院·口腔医院山西太原 030001;
2.山西省人民医院(山西省口腔健康防控技术创新中心) 山西太原 030012

收稿日期:2025-04-25 出版日期:2026-01-28 发布日期:2026-01-23
通讯作者: *石晶,E-mail:crystalshi@163.com
作者简介:赵璨(2000~ ),女,山西长治人,硕士在读,研究方向:口腔黏膜病及自身免疫性疾病。
基金资助:
山西省卫健委科研课题项目(编号:2020TD17)

Research Progress on Relationship between Gut Microbiota and Pemphigus Vulgaris

ZHAO Can¹, SHI Jing^1,2*

1. School and Hospital of Stomatology, Shanxi Medical University, Taiyuan 030001, China;
2. Shanxi Provincial People's Hospital, Shanxi Provincial Oral Health Prevention and Control Technology Innovation Center, Taiyuan 030012, China

Received:2025-04-25 Online:2026-01-28 Published:2026-01-23

摘要/Abstract

摘要： 在寻常型天疱疮(pemphigus vulgaris, PV)的发病过程中,环境因素起到至关重要的作用。肠道菌群作为重要的环境因素之一,近年来已被证实可影响多种自身免疫性疾病的进展。基于肠道菌群的干预措施已成为治疗自身免疫性疾病的新策略。近期研究显示,肠道微生态失调与PV的发生发展密切相关。本文综述了肠道菌群在PV发生发展中的作用、菌群紊乱影响PV的可能机制,以及以肠道菌群为靶点干预治疗PV的可能方式,为深入解析PV的发病机制及探索新型治疗途径提供了理论依据和研究思路。

关键词: 寻常型天疱疮, 肠道菌群, 发病机制, 菌群失衡

Abstract: Environmental factors play a pivotal role in the pathogenesis of pemphigus vulgaris (PV). As a significant environmental component, the gut microbiota has been increasingly recognized for its influence on the progression of various autoimmune diseases. Interventions targeting the gut microbiota have emerged as a novel therapeutic strategy for autoimmune disorders. Recent studies have demonstrated a strong correlation between gut dysbiosis and the development and progression of PV. This review comprehensively examines the role of gut microbiota in PV pathogenesis, potential mechanisms through which microbiota dysregulation influences PV, and potential therapeutic approaches targeting gut microbiota for PV intervention. The findings provide a theoretical foundation and research directions for elucidating the pathogenesis of PV and exploring innovative treatment strategies.

Key words: pemphigus vulgaris, intestinal microbiota, pathogenesis, microbiota imbalance

赵璨, 石晶. 肠道菌群与寻常型天疱疮关系的研究进展[J]. 口腔医学研究, 2026, 42(1): 12-16.

ZHAO Can, SHI Jing. Research Progress on Relationship between Gut Microbiota and Pemphigus Vulgaris[J]. Journal of Oral Science Research, 2026, 42(1): 12-16.

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肠道菌群与寻常型天疱疮关系的研究进展

Research Progress on Relationship between Gut Microbiota and Pemphigus Vulgaris

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