MAPK信号转导通路与慢性牙周炎的相关研究进展

doi:10.13701/j.cnki.kqyxyj.2017.09.025

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (9): 1012-1015.DOI: 10.13701/j.cnki.kqyxyj.2017.09.025

MAPK信号转导通路与慢性牙周炎的相关研究进展

赵娜¹，方慧²，唐亚平²，刘琪^3*

1. 遵义医学院附属口腔医院贵州遵义 563000；
2. 遵义医学院贵州遵义 563000；
3. 遵义医学院口腔医学系贵州遵义 563000

收稿日期:2016-06-14 出版日期:2017-09-20 发布日期:2017-09-27
通讯作者: 刘琪,电话:0852-8609758
作者简介:赵娜(1991~ ),女,贵州人,硕士在读,主要从事牙周病学临床及基础的研究学习。
基金资助:
国家自然科学基金(编号:81360168)

Advancement on Correction of MAPK Signal Pathway and Chronic Periodontitis

ZHAO Na¹, FANG Hui², TANG Ya-ping², LIU Qi^3*. School of Stomatology, Zunyi Medical College

1. School of Stomatology, Zunyi Medical College. Zunyi 563000, China;
2. Zunyi Medical College. Zunyi 563000, China;
3. Department of Stomatology, Zunyi Medical College. Zunyi 563000, China.

Received:2016-06-14 Online:2017-09-20 Published:2017-09-27

摘要/Abstract

摘要： 慢性牙周炎是一种病因极其复杂的疾病,目前为止,其发病机制待进一步澄清。近年来研究发现,MAPK信号通路在慢性牙周炎发病机制中处于重要地位,本文拟从MAPK信号通路在牙周组织免疫炎症及抗炎反应、牙槽骨的破坏与形成中所起到的作用作如下综述。

关键词: MAPK信号通路, 牙周炎, 发病机制

Abstract: Till now, the exact pathogenesis of chronic periodontitis still needs exploration. Recently, the MAPK signal transduction pathway has became a research hot spot in chronic periodontitis. This review focuses on the regulatory effects of MAPK signals in the inflammatory reactions and immune response in periodontium, and the destroy and regeneration in alveolar of chronic periodontitis.

Key words: MAPK signal pathway , Periodontitis , Mechanism

中图分类号:

R781.4

赵娜，方慧，唐亚平，刘琪. MAPK信号转导通路与慢性牙周炎的相关研究进展[J]. 口腔医学研究, 2017, 33(9): 1012-1015.

ZHAO Na, FANG Hui, TANG Ya-ping, LIU Qi. School of Stomatology, Zunyi Medical College. Advancement on Correction of MAPK Signal Pathway and Chronic Periodontitis[J]. Journal of Oral Science Research, 2017, 33(9): 1012-1015.

参考文献

[1] E LLIE T. K NIGHT , J ENNY L IU, et al. Risk factors that may modify theinnate and adaptive immuneresponses in periodontal diseases [J]. Periodontology, 2000, 2016,V 71(1)∶22-51
[2] Meister M, Tomasovic A, Banning A, Tikkanen R. Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount [J]. Int J Mol Sci, 2013, 14 (3)∶4854-4884
[3] Arthur JS,Ley SC. Mitogen-activated protein kinases in innate im-munity [J]. Nat Rev Immunol,2013,13(9)∶679-692
[4] Wagner EF,Nebreda AR. Signal integration by JNK and p38MAPK pathways in cancer development [J]. Nat Rev Cancer,2009,9(8)∶537-549
[5] Michael Karin;Ewen Gallagher From JNK to pay dirt: Jun kinases, their biochemistry, physiology and clinical importance [J]. IUBMB LIFE, 2005, 57(4)∶5283-5295
[6] Liu D, Cao G, Han L, et al. Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-kataB pathway with anti-inflammatory properties [J]. Cytokine,2016,25(84)∶29-36
[7] Ding Y, Boguslawski EA, et al. Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma [J]. Molecular Cancer Therapeutics, 2008, 7(3)∶648-658
[8] Shin BA, Yoo HG, et al. P38 MAPK pathway is involved in the urokinase plasminogen activator expression in human gastric SNU-638 cells [J]. ONCOLOGY REPORTS, 2003, 10(5)∶1467-1471
[9] Plotnikov A, Zehorai E, Procaccia S, et al. The MAPK cascades:signaling co mponents ,nuclear roles and mechanisms of nuclear translocation [J]. Biochimica Biophysica Acta, 2011, 1813(9)∶1619-1633
[10] 陈洁,姜虹.TLR4 信号通路与炎性反应[J]..医学综述,2009,15(19)∶2902-2904
[11] Marin M, Maria Giner R, Rios JL, et al. Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis [J]. Journal of Ethnopharmacology,2013,150(3) ∶925-934
[12] Drabarek B, Dymkowska D, Szczepanowska J, et al. TNF-α affects energy metabolism and stimulates biogenesis of mitochondria in EA. hy926 endothelial cells [J]. The International Journal of Biochemistry ＆ Cell Biology, 2012, 44(9)∶ 1390-1397
[13] Abarikwu SO. Kolaviron, a natural flavonoid from the seeds of Garcinia kola, reduces LPS- induced inflammation in macrophages bycombined inhibition of IL-6 secretion, and inflammatory transcription factors, ERK1/2, NF-κB, p38, Akt, p-c-JUN and JNK [J]. Biochim Biophys Acta, 2014, 1840(7)∶2373- 2381
[14] Ke Wu a,b , Shiliu Tian c ,Hillary Zhoud ,Yong Wud. Statins protect human endothelial cells from TNF-induced inflammation via ERK5 activation [J]. Biochemical Pharmacology, 2013, 85 (12)∶1753-1760
[15] Mee-Ran Shin et.al Won-Jung Bae HIF-2 inhibition suppresses inflammatory responses and osteoclastic differentiation in human periodontal ligament cells [J]. Journal of Cellular Biochemistry, 2015, 116(7)∶1241-1255
[16] 符智慧,徐凌,黄姣,尹东青.LPS通过p38/MAPK通路和NF-κB的活化诱导RAW264.7细胞HIF-1α的表达[J].重庆医科大学学报,2016
[17] Du A1, Zhao S2, Wan L3, et al. MicroRNA expression profile of human periodontal ligament cells under the influence of Porphyromonas gingivalis LPS [J]. Cell Mol Med,2016,20(10)∶1-10
[18] Anandarajah AP. Role of RANKL in bone diseases [J]. Trentls Endocrinol Metab, 2009, 20 (2)∶88-94
[19] Sik-Won Choi, Kie-In Park, Jeong-Tae, Yeonn, et al Anti-osteoclastogenic activity of matairesinol via suppressi;on of p38/ERK-NFATc1 signaling axis [J]. BMC Complement Altern Med,2014,14(1)∶1-8
[20] Sik-Won Choi, Young-Jin SonFisetinInhibitsOsteoclast Differentiation via Downregulation of p38 and c-Fos-NFATc1 SignalingPathways [J]. Evidence-based Complementary and Alternative Medicine, 2012, 120(12)∶1-9
[21] R. D. Chapurlat ;L. Palermo ;P. Ramsay, et al. Risk of fracture among women who lose bone density during treatment with alendronate. The Fracture Intervention Trial [J]. Osteoporosis International, 2005, 16(7)∶842-848
[22] Guo C, Yang XG, Wang F, et al. IL-1α induces apoptosis and inhibits the osteoblast differentiation of MC3T3-E1 cells through the JNK and p38 MAPK pathways [J]. Int J Mol Med, 2016
[23] Wang T, Wang Y, Yamashita H. Evodiamine inhibits adipogenesis via the EGFR-PKCa-ERK signaling pathway [J]. FEBS Lett, 2009, 583(22)∶3655-3659
[24] Wang X, Harimoto K, Liu J, et al. Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway [J]. Bone Miner Res, 2011, 26(8)∶1964-1973
[25] Gharibi, B;Ghuman, MS, et al. Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFR beta-induced MSC self-renewal [J]. Journal of Cellular and Molecular Medicine, 2012, 16(11)∶2789-2801
[26] Robert F. Klees; Roman M. Salasznyk, et al. Laminin-5 Induces Osteogenic Gene Expression in Human Mesenchymal Stem Cells through an ERK-dependent Pathway [J]. Molecular and Cellular Biology, 2005, 16(2)∶881-890
[27] Yumoto H, Hirao K, Tominaga T, et al. Electromagnetic Wave Irradiation Promotes Osteoblastic Cell Proliferation and Up-Regulates Growth Factors via Activation of the ERK1/2 and p38 MAPK Pathways [J]. Cellular Physiology and Biochemistry, 2015, 35(2)∶601-615
[28] Kim BS, Kang HJ, Park JY, Lee J. Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells [J]. Exp Mol Med, 2015, 47∶21-28

MAPK信号转导通路与慢性牙周炎的相关研究进展

Advancement on Correction of MAPK Signal Pathway and Chronic Periodontitis

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