口腔医学研究

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (1): 87-89.DOI: 10.13701/j.cnki.kqyxyj.2018.01.021

• 口腔种植学研究 • 上一篇    下一篇

IL-6和Shh在种植体周围炎龈沟液中的表达及意义

程志芬1, 崔连保2, 玄延花3*   

  1. 1. 郑州大学第一附属医院 郑州大学口腔医学院 河南 郑州 450001;
    2. 山东济南雅宝特口腔门诊 山东 济南 25000;
    3. 延边大学医学院 病理学教研部 吉林 延吉 133002
  • 收稿日期:2017-08-10 出版日期:2018-01-28 发布日期:2018-01-26
  • 通讯作者: 玄延花,电话:0433-2435107
  • 作者简介:程志芬(1987~ ),女,吉林省人,硕士,医师,主要从事口腔疾病分子病理学研究。
  • 基金资助:
    吉林省教育厅"十三五"科学技术研究项目(编号:吉教科合字[2016]第266号)

Expression of IL-6 and Shh in Gingival Crevicular Fluid of Patients with Peri-implantitis

CHENG Zhi-fen1, CUI Lian-bao2, XUAN Yan-hua3*   

  1. 1. The First Affiliated Hospital of Zhengzhou University, Stomatological College of Zhengzhou University, Zhengzhou 450001, China;
    2. The Yabaote Dental Clinic, Jinan 250021, China;
    3. Department of Pathology, Yanbian University College of Medicine, Yanji 133000, China.
  • Received:2017-08-10 Online:2018-01-28 Published:2018-01-26

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摘要： 目的:研究种植修复患者龈沟液中的IL-6和Shh的水平与种植体周围炎的关系及其意义。方法:根据25例种植体修复患者的种植体周围组织情况将其分为种植体健康组(10例)和种植体周围炎组(15例)。采用酶联免疫吸附试验(ELISA法)检测IL-6和Shh在种植体周围炎龈沟液和正常种植体周围龈沟液中的浓度。结果:IL-6和Shh在种植体周围炎组中的表达显著高于种植体健康组,且差异具有统计学意义(P<0.001)。IL-6与Shh无相关性(P>0.05)。结论:种植体周围龈沟液中IL-6和Shh浓度的升高可以较好地反映种植体周围组织的健康状态。Shh有可能成为评价种植体周围炎进展的生物标记物。

关键词: IL-6, Shh, 种植体周围炎, 龈沟液

Abstract: Objective: To study the expression of IL-6 and Shh in patients with peri-implantitis. Methods: Twenty-five patients were included and divided into health implant group (10 cases) and peri-implantitis group (15 cases). The expressions of IL-6 and Shh in health implant group and peri-implantitis group were detected by ELISA assay. Results: The expressions of IL-6 and Shh in the peri-implantitis group were significantly higher than those in the health implant group (P<0.001). There was no positive correlation between IL-6 and Shh (P>0.05). Conclusion: IL-6 and Shh were increased in gingival crevicular fluid of patients with peri-implantitis, and Shh might be a marker to determine the progress of peri-implantitis.

Key words: IL-6, Shh, Peri-implantitis, Gingival crevicular fluid

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