恶性高热的临床及基础研究进展

doi:10.13701/j.cnki.kqyxyj.2020.10.001

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (10): 893-897.DOI: 10.13701/j.cnki.kqyxyj.2020.10.001

• 特约述评 • 下一篇

恶性高热的临床及基础研究进展

唐瞻贵^*, 陈娟

中南大学湘雅口腔医院口腔颌面外科湖南长沙 410078

收稿日期:2020-08-11 出版日期:2020-10-28 发布日期:2020-10-19
通讯作者: *唐瞻贵,E-mail:tangzhangui@aliyun.com
作者简介:唐瞻贵,男,中共党员,医学博士,博士后,一级主任医师,二级教授,湘雅名医,博士生导师,享受国务院政府特殊津贴。现任中南大学湘雅口腔医院院长,口腔医学院院长,口腔医学研究所所长。中国整形美容协会口腔整形美容分会副会长,中华口腔医学会常务理事,中华口腔医学会口腔生物医学专委会常务委员,湖南省口腔医学会副会长,湖南省医师协会口腔医师分会会长。《口腔医学研究》副主编,《中华口腔医学杂志》、《中国口腔颌面外科杂志》等10余部杂志编委。主持国家自然科学基金等国家级课题5项,国家博士点基金、省科技厅重点项目等省部级项目20余项,获湖南省科技进步三等奖2项,湖南医学科技二等奖2项,主编参编著作10部,主持《口腔疣状癌临床诊治全国专家共识》及《口腔医学中恶性高热临床诊治中国专家共识》的讨论和撰写(中、英文)。

Advancements of Clinical and Basic Research in Malignant Hyperthermia.

TANG Zhangui^*, CHEN Juan

Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital, Central South University, Changsha 410078, China

Received:2020-08-11 Online:2020-10-28 Published:2020-10-19

摘要/Abstract

摘要： 恶性高热(malignant hyperthermia,MH)是一种较为罕见的遗传性疾病,主要表现为接触挥发性麻醉剂或去极化肌松剂时出现体温急剧升高,骨骼肌剧烈收缩进而引发一系列病理变化。患者发病前难以诊断,病情发展十分迅速,若得不到有效救治,则极易出现生命危险。随着各类麻醉药物在口腔临床中的广泛应用,口腔医生遇到MH的机率逐渐增加,且其治疗手段有一定的特殊性,若误诊误治可能导致患者死亡。因此,本文对MH的临床及基础研究进展行一综述。

关键词: 恶性高热, 诊断, 治疗

Abstract: Malignant hyperthermia (MH) is a rare genetic disease which characterized by a sharp rise in body temperature and a series of pathological changes caused by severe contraction of skeletal muscle when exposed to volatile anesthetics or depolarizing muscle relaxants. The patient is difficult to diagnose before the onset of the disease. The development MH is very rapid, and if not effectively treated, it is very easy to appear life-threatening. With the wide application of various anesthetics in the clinic, the probability to encounter MH is increasing gradually. However, the treatment methods are certain particular. Misdiagnosis and mistreatment may lead to the death of patients. Therefore, this paper reviews the clinical and basic research progress of MH.

Key words: malignant hyperthermia, diagnosis, treatments

唐瞻贵, 陈娟. 恶性高热的临床及基础研究进展[J]. 口腔医学研究, 2020, 36(10): 893-897.

TANG Zhangui, CHEN Juan. Advancements of Clinical and Basic Research in Malignant Hyperthermia.[J]. Journal of Oral Science Research, 2020, 36(10): 893-897.

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恶性高热的临床及基础研究进展

Advancements of Clinical and Basic Research in Malignant Hyperthermia.

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