巨噬细胞影响骨形成机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2021.11.002

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (11): 966-969.DOI: 10.13701/j.cnki.kqyxyj.2021.11.002

巨噬细胞影响骨形成机制的研究进展

聂张玲^1,2, 包崇云^1,2*

1.四川大学口腔疾病研究国家重点实验室四川成都 610041;
2.四川大学华西口腔医学院口腔颌面外科四川成都 610041

收稿日期:2020-07-03 出版日期:2021-11-28 发布日期:2021-11-22
通讯作者: *包崇云,E-mail:cybao9933@scu.edu.cn
作者简介:聂张玲(1997~),女,湖北人,博士在读,主要从事骨诱导生物学材料在颌骨缺损方面的应用及机制研究。
基金资助:
国家自然科学基金(编号:81870814)

Research Progress on Mechanism of Macrophages Affecting Bone Formation

NIE Zhangling^1,2, BAO Chongyun^1,2*

1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China;
2. Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China

Received:2020-07-03 Online:2021-11-28 Published:2021-11-22

摘要/Abstract

摘要： 巨噬细胞在骨形成中发挥关键作用,其具体的表现由多个复杂的生物学机制共同调控,巨噬细胞分泌的某些信号分子如抑瘤素M(OSM)、前列腺素E2(PGE2)、骨形态发生蛋白2(BMP-2)和肿瘤坏死因子-α(TNF-α)等在成骨过程中具有关键作用。另外,巨噬细胞的极化亚型也在成骨过程中发挥调控作用。本文对近年来巨噬细胞影响骨形成的相关机制研究进展进行综述。

关键词: 巨噬细胞, 骨形成, 间充质干细胞

Abstract: Macrophages play a key role in bone formation, and their specific performance is regulated by multiple complex biological mechanisms. Specifically, certain signaling molecules secreted by macrophages, such as oncostatin M (OSM), prostaglandin E2 (PGE2), bone morphogenetic protein-2 (BMP-2), and tumor necrosis factor-α (TNF-α), have a key role in osteogenesis. In addition, polarized subtypes of macrophages also play a regulatory role at different stages of osteogenesis. This article reviews the research progress of the related mechanisms of macrophages influencing bone formation in recent years.

Key words: macrophages, osteogenesis, mesenchymal stem cells

聂张玲, 包崇云. 巨噬细胞影响骨形成机制的研究进展[J]. 口腔医学研究, 2021, 37(11): 966-969.

NIE Zhangling, BAO Chongyun. Research Progress on Mechanism of Macrophages Affecting Bone Formation[J]. Journal of Oral Science Research, 2021, 37(11): 966-969.

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巨噬细胞影响骨形成机制的研究进展

Research Progress on Mechanism of Macrophages Affecting Bone Formation

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