牙周再生的困境、关键要素及研究进展

doi:10.13701/j.cnki.kqyxyj.2023.06.001

口腔医学研究 ›› 2023, Vol. 39 ›› Issue (6): 473-478.DOI: 10.13701/j.cnki.kqyxyj.2023.06.001

• 特约述评 • 下一篇

牙周再生的困境、关键要素及研究进展

闫福华^*, 袁志瑶

南京大学医学院附属口腔医院牙周病科江苏南京 210008

收稿日期:2023-03-29 出版日期:2023-06-28 发布日期:2023-06-21
作者简介:闫福华,南京大学医学院附属口腔医院副院长、教授、博士生导师。中华口腔医学会牙周病学专业委员会主任委员,中国医师协会口腔医师分会第五届副会长,江苏省口腔医学会副会长,享受国务院政府特殊津贴专家。“十三五”规划教材《牙周病学》副主编。主要研究领域为:牙周病与系统性疾病的关系、组织工程与牙周再生治疗、牙周病的种植修复治疗等。主持省部级及以上科研项目15项,其中国家自然科学基金项目7项;发表论文300余篇,其中《Bioactive Materials》、《Biomaterials》、《Theranostics》、《Applied Materials Today》、《Journal of Dental Research》、《International Journal of Oral Science》、《Journal of Clinical Periodontology》、《Journal of Periodontology》等学术刊物 80余篇。主编、主译学术专著25部。获省级科学技术进步奖二等奖1项,教育部科技进步奖二等奖1项,江苏省医学新技术引进一等奖1项。

The Challenges, Key Factors and Progress of Periodontal Regeneration Therapy

YAN Fuhua^*, YUAN Zhiyao

Department of Periodontology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China

Received:2023-03-29 Online:2023-06-28 Published:2023-06-21

摘要/Abstract

摘要： 牙周病治疗的最终目标是使牙周组织再生,然而目前临床上尚难以实现真正意义上的牙周再生。如何增加牙周再生的临床可预期性、恢复牙骨质-牙周膜-牙槽骨复合体的结构和功能仍是巨大的挑战。本文将对目前牙周再生治疗中面临的困境做一简述,并根据牙周再生过程中的关键要素,结合近年来的研究进展,探讨牙周再生过程中面临的挑战和可能的解决方案。

关键词: 牙周再生, 生物活性因子, 支架材料, 干细胞, 牙周炎症微环境

Abstract: The ultimate goal of periodontal disease treatment is to achieve periodontal tissue regeneration. However, it is difficult to achieve a true periodontal regeneration. Increasing the clinical predictability of periodontal regeneration and restoring the structure and function of cementum-periodontal ligament-alveolar bone complex remain great challenges. This article provides a brief overview of the challenges faced in periodontal regeneration treatment and explores the possible solutions based on the key elements of periodontal regeneration and recent research progress.

Key words: periodontal regeneration, bioactive factors, scaffold materials, stem cells, periodontal inflammatory microenvironment

闫福华, 袁志瑶. 牙周再生的困境、关键要素及研究进展[J]. 口腔医学研究, 2023, 39(6): 473-478.

YAN Fuhua, YUAN Zhiyao. The Challenges, Key Factors and Progress of Periodontal Regeneration Therapy[J]. Journal of Oral Science Research, 2023, 39(6): 473-478.

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牙周再生的困境、关键要素及研究进展

The Challenges, Key Factors and Progress of Periodontal Regeneration Therapy

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