褪黑素对正畸牙移动中牙槽骨代谢影响的研究进展

doi:10.13701/j.cnki.kqyxyj.2025.10.002

摘要/Abstract

摘要： 正畸牙移动是口腔正畸学中的核心治疗过程,牙槽骨的代谢是正畸牙移动的基础,包括压力侧骨吸收和张力侧的骨形成。在正畸外力作用下,牙周环境转变为炎性状态,牙槽骨的骨形成与骨吸收平衡被打破,骨吸收过度成为正畸治疗中较难控制的问题。褪黑素作为一种内源性吲哚类激素,近年来被发现具有调节生物节律、抗炎、抗氧化、免疫调节等多种生理功能。在炎性微环境下,褪黑素可通过骨保护作用、抗氧化、抗炎及血管功能调节等机制,促进骨代谢中的成骨效应。并且,褪黑素在骨代谢中发挥作用的关键通路与正畸牙移动牙槽骨代谢相关通路具有相似性,这些特性提示褪黑素在正畸牙移动过程的牙槽骨代谢中可能发挥重要作用。鉴于褪黑素对牙槽骨代谢的积极促进作用,本文就褪黑素在正畸牙移动过程中对牙槽骨代谢影响的研究进展进行综述。

关键词: 褪黑素, 牙槽骨代谢, 正畸牙移动, 炎性环境

Abstract: Orthodontic tooth movement is the core treatment process in orthodontics. The metabolism of alveolar bone, which includes bone resorption on the pressure side and bone formation on the tension side, forms the basis of orthodontic tooth movement. Under the action of orthodontic force, the periodontal environment transforms into an inflammatory state, which disrupts the balance between bone formation and bone resorption in the alveolar bone, and excessive bone resorption becomes a challenging issue to control in orthodontic treatment. As an endogenous indole hormone, melatonin has been demonstrated to process a variety of physiological functions in recent years, such as regulating biorhythms, anti-inflammation, anti-oxidation, and immunomodulation. In the inflammatory microenvironment, melatonin can promote the osteogenic effects in bone metabolism through mechanisms such as osteoprotection, antioxidation, anti-inflammation, and the modulation of vascular function. Moreover, the key pathways by which melatonin exerts its regulatory effects in bone metabolism are similar to those related to alveolar bone metabolism during orthodontic tooth movement, suggesting that melatonin may play a crucial role in alveolar bone metabolism during the process of orthodontic tooth movement. In view of the positive role of melatonin in alveolar bone metabolism, this paper reviews the research progress of effect of melatonin on alveolar bone metabolism during orthodontic tooth movement.

Key words: melatonin, alveolar bone metabolism, orthodontic tooth movement, inflammatory environment

钟润, 柳汀. 褪黑素对正畸牙移动中牙槽骨代谢影响的研究进展[J]. 口腔医学研究, 2025, 41(10): 838-843.

ZHONG Run, LIU Ting. Research Advances in Effect of Melatonin on Alveolar Bone Metabolism during Orthodontic Tooth Movement[J]. Journal of Oral Science Research, 2025, 41(10): 838-843.

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