天然药物活性成分防治放射诱导的唾液腺损伤及研究进展

doi:10.13701/j.cnki.kqyxyj.2025.10.003

摘要/Abstract

摘要： 放射治疗作为头颈部恶性病变的重要治疗手段,会引起不可逆的唾液腺放射损伤,严重影响患者的生活质量。天然药物因其良好的生物相容性和低毒性而备受关注。研究表明,这些活性成分通过抗氧化、抗炎和保护细胞免受氧化应激损伤等多重途径,调节细胞信号通路,减轻放射引起的炎症反应和细胞凋亡,从而保护唾液腺功能。本文综合分析了酚类、萜类、多糖类、苯丙素和苯乙醇苷类天然药物活性成分的最新研究,探讨了它们通过c-Jun N-末端激酶(c-Jun N-terminal kinase,JNK)、核因子-κB(nuclear factor kappa-B,NF-κB)、哺乳动物雷帕霉素靶蛋白(mechanistic target of rapamycin,mTOR)、p53等信号通路在防治放射诱导的唾液腺损伤中的作用机制和研究进展。

关键词: 唾液腺, 放射性损伤, 天然药物, 活性成分, 研究进展

Abstract: As an important treatment for malignant lesions of head and neck, radiotherapy can cause irreversible salivary gland radiation damage, which seriously affects the quality of life of patients.Natural medicine has attracted much attention due to its excellent biocompatibility and low toxicity.Studies have shown that these active ingredients regulate cell signaling pathways through multiple pathways such as antioxidant, anti-inflammatory and protection of cells from oxidative stress damage, alleviating radiation-induced inflammatory response and apoptosis, thereby protecting salivary gland function.This article comprehensively analyzes the latest research on the active components of natural drugs such as phenols, terpenes, polysaccharides, benzophenones, and benzopyrenes, and discusses their mechanisms of action and research progress in preventing radiation-induced salivary gland damage through c-Jun N-terminal kinase (JNK), nuclear factor kappa-B (NF-κB), mechanistic target of rapamycin (mTOR), and p53 signaling pathways.

Key words: salivary gland, radiation injury, natural medicine, active components, research progress

马宇硕, 许辉. 天然药物活性成分防治放射诱导的唾液腺损伤及研究进展[J]. 口腔医学研究, 2025, 41(10): 844-848.

MA Yushuo, XU Hui. Progress in Mechanism of Natural Drug Active Ingredients Against Radiation-induced Salivary Gland Damage[J]. Journal of Oral Science Research, 2025, 41(10): 844-848.

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