口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (2): 147-151.

• 临床研究论著 • 上一篇    下一篇

IFN-γ与口腔扁平苔藓相关性的meta分析

杨建堂*,顾令婉   

  1. 遵义医学院附属口腔医院口腔内科 贵州 遵义 563000
  • 收稿日期:2014-09-24 出版日期:2015-02-28 发布日期:2016-04-29
  • 通讯作者: 杨建堂,E-mail:945810934@qq.com
  • 作者简介:杨建堂(1985~ ),男,博士,云南人,主治医师,主要从事口腔内科的临床治疗工作。
  • 基金资助:
    遵义医学院博士启动基金(F-579)

Meta Analysis the Association between IFN-γ and OLP

YANG Jian-tang, GU Ling-wan   

  1. Department of Oral Medicine, Stomatology Hospital, Zunyi Medical College, Zunyi 563000
  • Received:2014-09-24 Online:2015-02-28 Published:2016-04-29

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摘要： 目的:研究IFN-γ的表达与口腔扁平苔藓之间的相关性。方法:电子检索PUBMED数据库、EMBase.com数据库、MEDLINE (OVID)数据库及CNKI数据库。收集相关的病例对照研究。两位研究者根据纳入排除标准,筛选出符合研究目的的文献,提取研究数据。数据统计采用RevMan 5.0软件进行分析,用meta分析对数据进行合并。对于异质性大的数据则根据具体的试验方法及研究对象采用亚组分析或敏感性分析。结果:检索筛选后最终纳入4篇中文和3篇英文文献。OLP患者IFN-γ血清水平、唾液水平与健康对照组之间无明显差异。糜烂型OLP组、网纹型OLP组与健康对照组间IFN-γ唾液水平无明显差异。糜烂型OLP组与网纹型OLP组间IFN-γ唾液水平无明显差异。OLP组IFN-γ在组织中阳性表达率高于健康对照组(P<0.01)。 结论:IFN-γ在OLP的发病及病程中可能发挥着重要作用,但其关系还有待于进一步探索。

关键词: 口腔扁平苔藓, IFN-γ, meta分析

Abstract: Objective: To explore the relationship between IFN-γand oral lichen planus. Methods: A systematic electronic search to hunt for any case control study about IFN-γ with lichen planus was established in the following databases: PUBMED, MEDLINE (OVID), EMBASE.com for papers in English language; CNKI for papers in Chinese language. Two investigators selected the original papers according to inclusive and exclusive criteria, described and evaluated the papers included in this review, then extracted the data independently. The different decisions between two investigators were discussed between each other. RevMan 5.0 from Cochrane was employed in data analysis of meta analysis.Results: 4 papers in Chinese and 3 papers in English were included in this review. There were no significant difference in the levels of IFN-γ in serum and saliva between OLP patients and healthy donors. There was no difference in the level of IFN-γ in saliva between erosive OLP (eOLP) patients and healthy donors, so was reticular OLP (rOLP) patients. There was no difference in the levels of IFN-γ in saliva between eOLP patients and rOLP patients. The positive rate of IFN-γ in tissue of OLP patients was significantly higher than healthy donors (P<0.01). Conclusion: IFN-γ may play an important role in OLP. However, more studies with high quality are expected to explore these fields.

Key words: Oral lichen planus , Immune, IFN-γ, Meta analysis

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