口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (7): 641-644.

• 基础研究论著 •    下一篇

Micro-CT对骨皮质切开术中区域性加速现象的分析

刘畅1,2,栾俐阳1,3,江久汇1*,李翠英1*,王海丞1,陈雅文1,4,许舒宇1,2,杨月1,彭靖1   

  1. 1. 北京大学口腔医学院 北京 100081;
    2. 山东大学口腔医学院;
    3. 滨州医学院口腔学院;
    4. 大连医科大学口腔医学院
  • 收稿日期:2014-10-23 出版日期:2015-07-28 发布日期:2015-07-28
  • 通讯作者: 江久汇,E-mail:drjiangw@163.com;李翠英,E-mail:licuiying_67@163.com
  • 作者简介:刘畅(1988~ ),北京人,女,硕士,从事口腔颌面外科的临床及基础研究,现工作于北京南区口腔医院正畸科。
  • 基金资助:
    国家自然科学基金(编号:303075816);国家自然科学基金(编号:81072214);北京市科学技术委员会首都临床特色应用研究基金(编号:303130219)

Analysis of Regional Accelerated Phenomenon in Corticotomy-assisted Orthodontic Treatment by Micro CT

LIU Chang, LUAN Li-yang, JIANG Jiu-hui, et al   

  1. Department of Oral and Maxillofacial Surgery, School of Stomatology, Peking Univeristy. Beijing 100081
  • Received:2014-10-23 Online:2015-07-28 Published:2015-07-28

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摘要： 目的:Micro-CT观测骨皮质切开辅助正畸治疗中牙齿移动速率和牙槽骨结构的改变。方法:选用75只4~6周龄的雄性SD大鼠,随机分为3组:组1:牙槽骨皮质切开辅助正畸(CO+TM),组2:传统正畸(TM),组3:单纯牙槽骨皮质切开(CO),按照时间点(加力4、7、14、21、28 d后)处死实验动物并进行Micro-CT扫描,测量牙移动距离;三维重建后测量牙颈部、根中部、根尖部3个平面张力侧及压力侧共6个区域的牙槽骨骨密度及骨体积。结果:1)牙移动距离:初期TM组高于CO+TM组,在第14、21、28天时,CO+TM组明显高于TM组(P<0.05)。速率:4~7 d时TM组大于CO+TM组,之后小于CO+TM组,组间比较P<0.05。2)骨密度:4、7、21、28 d时远中骨密度CO+TM组与CO、TM组比较持续下降,TM组则先下降后上升,CO组稳定于0左右(P<0.05)。3)骨体积:CO+TM组近中骨体积始终呈下降趋势,TM组近中骨体积自加力4 d后持续缓慢升高。结论:牙槽骨骨皮质改良切开术辅助正畸可以在术后14~28 d内增加正畸牙移动距离;牙槽骨远中侧骨密度降低明显,压力侧骨体积下降,张力侧骨体积上升,骨改建活跃,区域性加速现象在21 d时最明显。

关键词: 牙槽骨骨皮质切开, Micro-CT, 骨密度, 骨体积, 区域性加速现象

Abstract: Objective: To observe the rate of tooth movement and the structure of alveolar bone in corticotomy-assisted orthodontic treatment by Micro-CT. Methods: 75 four or six-week male SD rats were used in this study. The rats were randomly divided into 3 groups:group1-CO+TM, group2-TM, group3-CO, with 5 in each one group. The rats were sacrificed at different times(t=4,7,14,21,28days). Micro-CT was used to measure the change of tooth movement and the structure of alveolar bone. Results: In terms of the amount of tooth movement, our results illustrated that the CO+TM group had a small amount at the beginning of the study compared with the TM group, CO+TM group was obvious higher than TM group from day 14 to 28(P<0.05). From day 4 to 7, TM was faster than CO+TM, then slower than CO+TM. When compared to CO and TM, CO+TM continued to drop at day 4,7,21,28. TM group went up at first and then went down. CO group was stable at 0(P<0.05). The bone volume in mesial of CO+TM group always decreased. As to TM group, the volume decreased in the early, but rebound after the 4th day. Conclusion: Alveolar bone corticotomy-assisted orthodontic treatment can accelerat the rate of tooth movement from day 14 to 28. There is a phenomenon called "regional accelerated phenomenon(RAP)" occured at day 21, It is associated with increased perfusion and bone turnover and decreased bone density.

Key words: AOO, Micro-CT, Bone volume, Boneminaral density, RAP

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