口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (7): 676-680.DOI: 10.13701/j.cnki.kqyxyj.2016.07.003

• 基础研究论著 • 上一篇    下一篇

“脑回形(cortex-like)”微弧氧化膜钛种植体成骨的Micro-CT分析

周宏志1*, 李亚达2, 刘唤3, 刘琳1, 王伟强2, 马国武3, 齐民2   

  1. 1. 大连市口腔医院寺儿沟门诊部 辽宁 大连 116021;
    2. 大连理工大学材料与工程学院 辽宁 大连 116021;
    3. 大连医科大学口腔医学院 辽宁 大连 116021
  • 收稿日期:2015-12-14 出版日期:2016-07-26 发布日期:2016-07-25
  • 通讯作者: 周宏志,E-mail:zhz1994@163.com
  • 作者简介:周宏志(1973~ ),男,黑龙江人,主任医师,博士,主要从事口腔种植的临床及基础研究工作。
  • 基金资助:
    国家自然科学基金(编号:51371042);教育部博士点基金(编号:20130041110005);大连市科技局基金项目(编号:2014E14SF164)

Micro-CT Analysis of Osseointegration of Cortex-like Titania Implant Coatings with Micro-arc Oxidation.

ZHOU Hong-zhi1, LI Ya-da2, LIU Huan3, LIU Lin1, WANG Wei-qiang2, MA Guo-wu3, QI Min2   

  1. 1. Siergou Outpatient Department, Stomatological Hospital of Dalian, Dalian 116021, China;
    2. Materials and Engineering College, Dalian University of Technology, Dalian 116021, China;
    3. Hospital of Stomatology, Dalian Medical University, Dalian 116021, China
  • Received:2015-12-14 Online:2016-07-26 Published:2016-07-25

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摘要： 目的: 利用Micro-CT评价“大脑皮质”(cortex-like)形貌的二氧化钛膜层在初始稳定性和继发稳定性阶段的骨-种植体结合的能力。方法: 实验组MAO(cortex-like)为 “大脑皮质”形貌种植体,对照组SLA为具有同等规格的SLA形貌的种植体,共计36颗,通过扫描电镜(SEM)等对材料表面进行表征,随机植入18只新西兰雄性兔的股骨髁部,分别于4周和8周处死取样,所得标本行Micro-CT扫描重建,分析MAO和SLA种植体表面的骨结合状况以及的骨小梁形态学参数。结果: 类“大脑皮质”形貌氧化层由微米级沟槽和纳米级孔洞组成,沟槽相互交通,接触角(6.9±1.14)°,Micro-CT检测可见:随着骨结合时间的延长,骨体积分数(BV/TV)、骨小梁数量(Tb.N)、厚度(Tb.Th)、连接密度增加(Conn.Dn)均增加,结构模型指数(SMI)、骨小梁分离度(Tb.Sp)下降,第4周时,BV/TV,SMI组间比较差异存在统计学意义(P<0.05),第8周时,BV/TV、Tb.N、Tb.Sp、Conn.Dn值组间比较差异存在统计学意义(P<0.05),MAO高于SLA组。结论: “大脑皮质”(cortex-like)形貌的二氧化钛、具有双微层结构膜层,能促进种植体的骨结合的提升,是一种良好的种植体改性方法。

关键词: 钛种植体, 微弧氧化, 大脑皮质形貌, Micro-ct, 骨小梁

Abstract: Objective: To assess the osseointegration of porous titania (TiO2) coating with a novel cortex-like morphology by micro-CT. Methods: Cortex-like morphology Ti surface was produced by MAO, and SLA surface was used as control.The surface features were evaluated by scanning electron microscope (SEM) and contact Angle. Thirty-six threaded implants were placed in the femoral condyles of 18 male New Zealand White rabbits. Trabecular bone morphology parameters were analyzed after implantation 4 weeks and 8 weeks by Micro-CT. Results: Morphology microstructure of MAO cortex-like was composed of microscale and nanoscale structure, with better wettability and contact Angle (6.9±1.14)°. Along with the time of bone healing, the BV/TV, Tb. N, Tb. Th and Conn. Dn were increased, while SMI and Tb. Sp were decreased. At 4th week, statistical significances were detected in BV/TV and SMI (P<0.05). At 8th week, statistical significances were detected in BV/TV, Tb. N, Tb. Sp and Conn.Dn (P<0.05). Cortex-like morphology exhibited more continuous bone apposition. Conclusion: The cortex-like morphology of titanium with microscale and nanoscale topologic structure can improve the osseointegration of Ti implant and has good biocompatibility.

Key words: Titanium implant , Micro-arc oxidation , Cortex-like morphology, Micro-CT, Trabecnlav

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