Abstract: Objective: To investigate sedative, analgesic effects of propofol plus hydromorphone given to postoperative patients with tracheostomy tube in oral and maxillofacial surgery. Methods: Forty patients with endotracheal tube after surgical treatment in oral and maxillofacial surgery were randomly divided into P-H group (propofol plus hydromorphone), P-D group (propofol plus dexmedetomidnie). P-H group received propofol 0.5-1.0 mg/kg/h intravenous infusion plus hydromorphone 4-8μg/kg/h, and P-D group received propofol 0.5-1.0 mg/kg/h intravenous infusion plus dexmedetomidnie 0.2-0.6μg/kg/h. Ramsay score, heart rate, blood pressure, respiratory and other changes were compared between two groups. Time check points included before administration (T0), 30 minutes after administration (T1), 1 hour after administration (T2), 2 hours after administration (T3), 6 hours after administration (T4), 12 hours after administration (T5) and 10 minutes after extubation (T6). The data were processed with SPSS 16.0 software package. Results: There was no significant difference for arterial blood gas analysis, oxygen saturation, mean arterial pressure, respiratory rate and ramsay score between two groups at all time points. However,the changes of heart rate were significantly different between the two groups at T2,T5 and T6. Conclusion: Similar sedative and analgesic effects can be gained in treating postoperative patients with tracheostomy tube in oral and maxillofacial surgery with P-H compared to with P-D. Besides, the former does not result in bradycardia.