Association between THADA Gene Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate.

doi:10.13701/j.cnki.kqyxyj.2017.02.017

Abstract

Abstract: Objective: To explore the association between three single nucleotide polymorphisms (SNPs) rs7590268, rs13035011 and rs6729902 of THADA gene and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in the northern Chinese population. Methods: Multiple PCR and multiple ligase detection reaction were used to analyze three SNPs (rs7590268, rs13035011 and rs6729902) of THADA in 335 NSCL/P patients and 325 healthy individuals. Results: There were significant differences in rs7590268 and rs6729902 allelic distribution between cleft lip only and the control group (P<0.05). However, there were no significant differences in either genotypic or allelic distribution of rs13005011 between the patients and the controls. Conclusion: The SNPs of rs7590268 and rs6729902 in THADA gene may be associated with NSCL/P in the northern Chinese population.

Key words: Nonsyndromic cleft lip with or without cleft palate , Thyroid adenoma associated , Single nucleotide polymorphisms

CLC Number:

R782.2

LI Dong-mei, LIU Ting-ting, MENG Xiang-biao, HAO Yan-ru, JIAO Xiao-hui, LV Ke-wen, SHI Jin-na, GUO Qiang, SONG Tao. Association between THADA Gene Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate.[J]. Journal of Oral Science Research, 2017, 33(2): 187-190.

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