Co-effects of Ethnicity and Periodontal Health Status on Oral Microbiome Diversity.

doi:10.13701/j.cnki.kqyxyj.2017.07.014

Abstract

Abstract: Objective: To explore the effects influenced by the status of periodontal health and different ethnicity on oral microbial diversity by high throughput sequencing. Methods: Saliva was collected from 12 periodontitis patients (5 Han and 7 Yugur) and 10 healthy sub-jects (5 Han and 5 Yugur). The total DNA of bacterias was extracted, then the sequence of 16S rRNA gene was sequenced by Illumina MiSeq high throughput sequencing platform. Results: In the UniFrac distance total variation observation, the periodontal factors only explained the variation in the unweighted analysis, and the ethnic factors just explained the variation in the weighted analysis. The interaction of the two influencing factors explained the variation in both unweighted and weighted analysis. Conclusion: Periodontal health status and ethnic factors have effects on oral microbial diversity, and there may be synergistic effects, but periodontal health status is the main factor in changing the bacterial composition.

Key words: Ethnicity, Periodontal health status, α-diversity , β-diversity , Microbial composition

CLC Number:

R781.4

MA Rui, SHI Wen, YI Gen-yun, ZHANG Xiao-feng, HUANG Hui-min, ZHOU Jian-ye, YU Zhan-hai, LI Zhi-qiang.. Co-effects of Ethnicity and Periodontal Health Status on Oral Microbiome Diversity.[J]. Journal of Oral Science Research, 2017, 33(7): 745-749.

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