Abstract: Objective: To evaluate the clinical and radiographic effects of pulp revascularization procedure on immature teeth with apical periodontitis. Methods: In this study, clinical and radiographic data were collected every 3 months from 20 immature permanent teeth with apical periodontitis treated with a revascularization protocol for 18 months. Clinical and radiographic evidence of healing was evaluated, and radiographic changes in the radiographic root area and apical diameter were quantified. Results: After a follow-up period of 18 months, all teeth demonstrated radiographic evidence of complete periapical healing in the absence of clinical symptoms. Five teeth showed a positive response to pulp sensibility test after 18 months. The within-case percent change in radiographic root area was 28.13% after 3 months and had increased to 99.28% after 18 months. The within-case percent change in apical diameter after 3 month was 21.43% and had increased to 77.05% by 18 months, with 50% (10 of 20) showing complete apical closure after 18 months. Conclusion: In this study, pulp revascularization allowed the continued development of roots in immature permanent teeth with apical periodontitis.

Key words: Immature permanent teeth, Pulp revascularization, Clinical research, Radiographic outcomes