Effect of Cathepsin K Inhibitor on Remodeling of Periodontium during Orthodontic Tooth Movement.

doi:10.13701/j.cnki.kqyxyj.2017.12.003

Journal of Oral Science Research ›› 2017, Vol. 33 ›› Issue (12): 1250-1253.DOI: 10.13701/j.cnki.kqyxyj.2017.12.003

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Effect of Cathepsin K Inhibitor on Remodeling of Periodontium during Orthodontic Tooth Movement.

HUANG Li, ZHOU Ze-yuan, WANG Xin, SU Chen-xi, ZOU Shu-juan^*.

Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Received:2017-06-27 Online:2017-12-20 Published:2018-01-03

Abstract

Abstract: Objective: To investigate the effect of cathepsin K inhibitor on remodeling of periodontium during orthodontic tooth movement. Methods: Forty-two Wistar rats were subjected orthodontic tooth movement for 3, 7 and 14 days. Six rats were sacrificed immediately as initial control, the rest of rats were randomly divided into ODN group received local injection every third day with ODN and control group with saline of the same dose. Samples were collected at the 14th day after tooth movement period. The results were assessed by HE and IHC of Cat-K and COL I. Results: Cat-K mainly expressed in the pressure area and the positive expression of ODN group was less than the control group. COL I mainly expressed in the tension area and the positive expression of ODN group was more than the control group. The IHC results of Cat-K and COL I both had statistical significant difference on the 7th and 14th day. Conclusion: The Cat-K inhibitor odanacatib played a role in remodeling during orthodontic tooth movement. It could inhibit the expression of Cat-K and promote the secretion of COL I.

Key words: Othodontic tooth movement, Cathepsin, K inhibitor, Cat-K, COL I

CLC Number:

R783.5

HUANG Li, ZHOU Ze-yuan, WANG Xin, SU Chen-xi, ZOU Shu-juan.. Effect of Cathepsin K Inhibitor on Remodeling of Periodontium during Orthodontic Tooth Movement.[J]. Journal of Oral Science Research, 2017, 33(12): 1250-1253.

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Effect of Cathepsin K Inhibitor on Remodeling of Periodontium during Orthodontic Tooth Movement.

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