Research Progress of Stress Response-related Two Component Signal Transduction Systems of Streptococcus Mutans

doi:10.13701/j.cnki.kqyxyj.2018.08.004

Abstract

Abstract: Streptococcus mutans (S. mutans) is considered one of the primary etiological agents of dental caries. The two component signal transduction pathways network of S. mutans is comprised of histidine protein kinase and response regulator protein. Two component systems (TCSs) enable S. mutans to sense the environments changes and regulate the expression of important genes, which are essential for the survival and virulence adjustment of S. mutans. This article comprehensively reviews the current progress of the TCSs systems closely associated with stress response of S. mutans.

Key words: Two component signal transduction systems, Stress response, VicRK, LiaRS, CiaRH, ComDE

ZHAO Xin-yuan, CUI Li. Research Progress of Stress Response-related Two Component Signal Transduction Systems of Streptococcus Mutans[J]. Journal of Oral Science Research, 2018, 34(8): 815-817.

References

[1] Biswas I, Drake L, Erkina D, et al. Involvement of sensor kinases in the stress tolerance response of Streptococcus mutans [J]. J Bacteriol, 2008, 190(1)∶68-77
[2] Tremblay YD, Lo H, Li YH, et al. Expression of the streptococcus mutans essential two-component regulatory system VicRK is PH and growth-phase dependent and controlled by the LiaFSR three-component regulatory system [J]. Microbio, 2009,155 (9)∶2856-2865
[3] Senadheera MD, Guggenheim B, Spatafora GA, et al. A VicRK signal transduction system in streptococcus mutans affects gtfBCD, gbpB, and ftf expression, Biofilm formation, and genetic competence development [J]. J Bacteriol, 2005,187(12)∶4064-4076
[4] Negrini TC, Duque C, Vizoto NL, et al. Influence of VicRK and CovR on the interactions of Streptococcus mutans with phagocytes [J]. Oral Dis, 2012, 18(5)∶485-493
[5] Senadheera MD, Lee AW, Hung DC, et al. The streptococcus mutans vicX gene product modulates gtfB/C expresssion, biofilm formation, genetic competence, and oxidative stress tolerance [J]. J Bacteriol, 2007, 189(4)∶1451-1458
[6] Lei L, Yang Y, Mao M, et al. Modulation of biofilm exopolysaccharides by the Streptococcus mutans vicX gene [J]. Front Microbiol, 2015, 21(6)∶1432
[7] Stipp RN, Boisvert H, Smith DJ, et al. CovR and VicRK regulate cell surface biogenesis genes required for biofilm formation in Streptococcus mutans [J]. PLoS One, 2013, 8(3)∶e58271
[8] Alves LA, Harth-Chu EN, Palma TH, et al. The two-component system VicRK regulates functions associated with Streptococcus mutans resistance to complement immunity [J]. Mol Oral Microbiol, 2017, 32(5)∶419-431
[9] Suntharalingam P, Senadheera MD, Mair RW, et al. The LiaFSR system regulates the cell envelope stress response in streptococcus mutans [J]. J Bacteriol, 2009, 191(9)∶2973-2984
[10] Zhang J, Biswas I. A phenotypic microarray analysis of streptococcus mutans liaS mutant [J]. Microbiology, 2009, 155(1)∶61-68
[11] Perry JA, Lévesque CM, Suntharaligam P, et al. Involvement of streptococcus mutans regulator RR11 in oxidative stress response during biofilm growth and in the development of genetic competence [J]. Lett Appl Microbiol, 2008, 47(5)∶439-444
[12] Qi F, Merritt J, Lux R, et al. Inactivation of the ciaH gene in Streptococcus mutans diminishes mutacin production and competence development, alters sucrose-dependent biofilm formation, and reduces stress tolerance [J]. Infect Immun, 2004, 72(8)∶4895-4899
[13] He X, Wu C, Yarbrough D, et al. The cia operon of Streptococcus mutans encodes a unique component required for calcium-mediated autoregulation [J]. Mol Microbiol, 2008, 70(1)∶112-126
[14] Wu C, Ayala EA, Downey JS, et al.Regulation of ciaXRH Operon Expression and Identification of the CiaR Regulon in Streptococcus mutans [J]. J Bacteriol, 2010, 192(18)∶4669-4679
[15] Mazda Y, Kawada-Matsuo M, Kanbara K, et al. Association of CiaRH with resistance of Streptococcus mutans to antimicrobial peptides in biofilms [J]. Mol Oral Microbiol, 2012, 27 (2)∶124-135
[16] Liu Y, Burne RA. Multiple two-component systems of streptococcus mutans regulate agmatine deiminase gene expression and stress tolerance [J]. J Bacteriol, 2009, 191(23)∶7363-7366
[17] Leung V, Ajdic D, Koyanagi S et al. The formation of Streptococcus mutans persisters induced by the quorum-sensing peptide pheromone is affected by the LexA regulator [J]. J Bacteriol, 2015, 197(6)∶1083-1094
[18] Liu J, Ling JQ, Zhang K, et al. Physiological properties of Streptococcus mutans UA159 biofilm-detached cells [J]. FEMS Microbiol Lett, 2013, 340(1)∶11-18
[19] Ahn SJ, Qu MD, Roberts E, et al. Identification of the Streptococcus mutans LytST two-component regulon reveals its contribution to oxidative stress tolerance [J]. BMC Microbiol, 2012, 12∶187
[20] Tremblay YD, Lo H, Li YH, et al. Expression of the Streptococcus mutans essential two-component regulatory system VicRK is pH and growth-phase dependent and controlled by the LiaFSR three-component regulatory system [J]. Microbiology, 2009, 155(9)∶2856-2865
[21] Downey JS, Mashburn-Warren L, Ayala EA, et al. In vitro manganese-dependent cross-talk between Streptococcus mutans VicK and GcrR: implications for overlapping stress response pathways [J]. PLoS One, 2014, 9(12)∶e115975
[22] Eguchi Y, Kubo N, Matsunaga H, et al. Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C [J]. Antimicrob Agents Chemother, 2011, 55(4)∶1475-1484
[23] Ayala E, Downey JS, Mashburn-Warren L, et al. A biochemical characterization of the DNA binding activity of the response regulator VicR from Streptococcus mutans [J]. PLoS One, 2014, 9(9)∶e108027