Abstract: Objective: To verify the hypothesis that the incorporation of strontium (Sr) or zinc (Zn) into electrodeposited calcium phosphate coatings (ECP) does not influence the proliferative ability and differentiation potential of osteoclasts. Methods: Titanium alloy plates electrolytically coated with calcium phosphates with or without Sr or Zn were incubated with osteoclast-like RAW264.7 cells for eight days. The proliferation index within 6 days and the differentiation after 8 days were analyzed. Results: Although presenting different cell attachment pattern, the osteoclast-like cells demonstrated similar differentiation potential. Coatings with Zn presented statistical lower cell proliferative ability. Conclusion: Electrodeposited calcium phosphate coatings with Zn enhanced the attachment of osteoclasts. The incorporation of Sr and Zn to the electrodeposited calcium phosphate coatings does not influence the proliferation and differentiation of osteoclast-like cells

Key words: Strontium, Zinc, Calcium phosphate coating, Osteoclast-like cell