Abstract: Objective: To investigate the effects of nano-silver inorganic zirconium phosphate on physical and chemical properties of denture base resin.Methods: Nano-inorganic silver zirconium phosphate was added into the resin base at concentrations of 1%, 3%, 5% and 7%, and without additive as a control group (0%).The surface hardness, flexural strength, compressive strength, tensile strength, water absorption value, dissolved value, and infrared spectrum were measured according to the national standards.Results: The maximum hardness was (164.60±6.83) MPa in 7% group.Compared with control group, each adding group showed significantly differences (P<0.05).Compared with 1% group, the flexural strength of 3% group reached (97.53±10.00) MPa, the compression strength reached (316.00±9.89) MPa, and the tensile strength reached (64.86±5.02) MPa (P<0.05).There was no significant change in water absorption and dissolution between the groups (P>0.05).In addition, there was a peak at about 550 cm^-1，wavelength on the infrared spectrum of each addition group, which was assigned to phosphate group.Conclusion: The resin base got the best physical and chemical properties at 3% nano-silver inorganic zirconium phosphate.Infrared spectrum analysis showed that nano-supported silver zirconium phosphate was successfully added to PMMA.

Key words: Removable partial dentures, Modified base resin, Antibacterial agent, Physical and Chemical properties