Journal of Oral Science Research

Journal of Oral Science Research ›› 2019, Vol. 35 ›› Issue (1): 23-27.DOI: 10.13701/j.cnki.kqyxyj.2019.01.006

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Imbalanced Post-operative Weight Loss in Combined Obesity and Periodontitis Models

YU Ting1, ZHAO Li2, ZHANG Jin-cai3, XUAN Dong-ying4*   

  1. 1. Department of Periodontology, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou 510140, China;
    2. Department of Prosthodontics, Guanghua School of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China;
    3. Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China;
    4. Department of Periodontology, Hangzhou Dental Hospital, Savaid Medical School, University of Chinese Academy of Sciences, Hangzhou 310006, China
  • Received:2018-05-28 Online:2019-01-18 Published:2019-01-28

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Abstract: Objective: To explore the effects of main experimental factors on post-operative weight loss (POWL) when establishing combined obesity and periodontitis models. Methods: Combined models of diet-induced obesity and ligation-induced periodontitis were established. Effects of feeding duration (8, 16 and 30 weeks), diet, ligation and ligation duration (5 and 10 days) on POWL were evaluated by 4-way ANOVA. Results: DIO and periodontitits mice had 70% (10.4% vs. 6.1%, P<0.001) and 30% (9.6% vs. 7.4%, P=0.002) higher POWL, respectively, in contrast to their corresponding controls. As severity of obesity increased, POWL of the DIO mice was elevated and more difficult to recover and POWL difference between DIO mice and the controls was further enhanced. More POWL went with longer ligation duration after specific feeding duration (16 weeks). Conclusion: When establishing combined obesity and periodontitis models, imbalanced POWL occurs within groups of the main experimental factors (including obesity and periodontitis and their severity), which should be critically assessed to minimize its potential disturbance on experimental objectives.

Key words: Confounding effect, Obesity, Periodontal diseases, Weight loss