Abstract: Objective: To investigate the relationship between the distribution of age and tumor biomarkers in patients with oral squamous cell carcinoma. Methods: The data of patients with oral squamous cell carcinoma were collected from TCGA database and Hospital of Stomatology, Wuhan University. The correlation analysis was conducted between the distribution of age and the expression of p53, CCND1, EGFR, and SOX2. Further correlation analysis was conducted between p53 gene mutation and the distribution of age. Results: Patients with age between 51 and 70 years were the most affected population in oral squamous cell carcinoma. No significant difference on the expression of CCND1, EGFR, and SOX2 was found among different age groups. However, a 1.5- to 1.7-fold increased expression of EGFR was observed in patients younger than 51 years old. Patients with age between 61 to 70 years showed significantly lower expression of p53 than other age groups. No significant difference on the incidence of p53 mutation was found among age groups. However, patients with wild type p53 had significantly higher levels of p53 mRNA than those with mutant p53. Conclusion: Patients with age between 51 and 70 years are the most affected population in oral squamous cell carcinoma. Patients with age between 61 to 70 years showed significantly lower expression of p53 than other age groups.

Key words: Oral squamous cell carcinoma, Age, p53