Research Progress of Radiotherapy on Bone Tissue and Osseointegration around Implants

doi:10.13701/j.cnki.kqyxyj.2020.03.005

Abstract

Abstract: Implant dentures have become the best method to repair teeth defect and tooth loss in adult patients. For patients with head and neck cancer, surgical excision combined with radiotherapy and chemotherapy is usually required. However, local radiotherapy may cause some damage to the quality and quantity of jaw tissue, which may indirectly affect the osseointegration of the implant. In this paper, the effects of radiotherapy on bone tissue and osseointegration around the implant are reviewed.

Key words: radiotherapy, osseointegration, implant

YU Kaixuan, ZHOU Yanmin. Research Progress of Radiotherapy on Bone Tissue and Osseointegration around Implants[J]. Journal of Oral Science Research, 2020, 36(3): 209-212.

References

[1] Branemark PI, Hansson BO, Adell R, et al. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period[J]. Scand J Plast Reconstr Surg Suppl,1977,16:1-132.
[2] Baglink DJ, Wergedal JE, Yamamoto K, et al. Systemic factors in alveolar bone loss[J]. J Prosthet Dent,1974,31(5):486-505.
[3] Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
[4] Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005[J].CA Cancer J Clin, 2010, 55(1):10-30.
[5] L.F.法哈多. 辐射损伤病理学[M]. 原子能出版社, 1988:82.
[6] 郭瑶. 放射损伤病理学[M]. 人民卫生出版社,1987:352.
[7] Marx RE, Johnson RP. Studies in the radiobiology of osteoradionecrosis and their clinical significance[J].Oral Surg Oral Med Oral Pathol,1987,64(4):379-390.
[8] Chandra A, Park SS, Pignolo RJ. Potential role of senescence in radiation-induced damage of the aged skeleton[J].Bone, 2019, 120:423-431.
[9] Williams H, Davies A. The effect of X-rays on bone: a pictorial review[J]. Eur Radiol, 2006, 16(3):619-633.
[10] Barth HD, Zimmermann EA, Schaible E, et al. Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone[J]. Biomaterials, 2011, 32(34):8892-8904.
[11] Muhonen A, Säämänen AM, Peltomäki T, et al. The effect of irradiation and hyperbaric oxygenation (HBO) on extracellular matrix of the condylar cartilage after mandibular distraction osteogenesis in the rabbit[J]. Int J Oral Maxillofac Surg, 2006, 35(1):79-87.
[12] Muhonen A, Haaparanta M, Grönroos T, et al. Osteoblastic activity and neoangiogenesis in distracted bone of irradiated rabbit mandible with or without hyperbaric oxygen treatment[J]. Int J Oral Maxillofac Surg, 2004, 33(2):173-178.
[13] Zhang WB, Zheng LW, Chua DTT, et al. Expression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis[J]. Int J Oral Maxillofac Surg, 2011, 69(11):2860-2871.
[14] Zhang WB, Zheng LW, Chua D, et al. Bone regeneration after radiotherapy in an animal model[J]. Int J Oral Maxillofac Surg, 2010, 68(11):2802-2809.
[15] 路正刚,刘洪臣,王所亭,等.放疗对狗下颌纯钛种植体与骨接触作用的影响[J].口腔颌面修复学杂志,2004,5(3):168-171.
[16] Wright LE, Buijs JT, Kim HS, et al. Single-limb irradiation induces local and systemic bone loss in a murine model[J]. J Bone Miner Res, 2015, 30(7):1268-1279.
[17] Turner RT, Iwaniec UT, Wong CP, et al. Acute exposure to high dose γ-radiation results in transient activation of bone lining cells[J]. Bone, 2013, 57(1):164-173.
[18] Green DE, Adler BJ, Chan ME, et al. Altered composition of bone as triggered by irradiation facilitates the rapid erosion of the matrix by both cellular and physicochemical processes[J]. PLoS One, 2013, 8(5):e64952.
[19] Guo C, Li C, Yang K, et al. Increased EZH2 and decreased osteoblastogenesis during local irradiation-induced bone loss in rats[J]. Sci Rep, 2016, 6:31318.
[20] Jia D, Gaddy D, Suva LJ, et al. Rapid loss of bone mass and strength in mice after abdominal irradiation[J]. Radiat Res, 1938, 176(5):624-635.
[21] Gong B, Oest ME, Mann KA, et al. Raman spectroscopy demonstrates prolonged alteration of bone chemical composition following extremity localized irradiation[J]. Bone, 2013, 57(1):252-258.
[22] Green DE, Rubin CT. Consequences of irradiation on bone and marrow phenotypes, and its relation to disruption of hematopoietic precursors[J]. Bone, 2014, 63(6):87-94.
[23] Sawada K, Fujiokakobayashi M, Kobayashi E, et al. In vitro effects of 0 to 120 Grays of irradiation on bone viability and release of growth factors[J]. Bmc Oral Health, 2017, 17(1):1-8.
[24] Alwood JS, Shahnazari M, Chicana B, et al. Ionizing radiation stimulates expression of pro-osteoclastogenic genes in marrow and skeletal tissue[J]. J Interf Cytok Res, 2015, 35(6):480-487.
[25] Zen Filho EV, Tolentino EDS, Santos PSS. Viability of dental implants in head and neck irradiated patients: A systematic review[J]. Head Neck, 2016, 38(S1):E2229-E2240.
[26] Schiegnitz E, Al-Nawas B, Kömmerer PW, et al. Oral rehabilitation with dental implants in irradiated patients: a meta-analysis on implant survival[J]. Clin Oral Invest, 2015, 19(7):1693-1693.
[27] Tanaka TI, Chan HL, Tindle DI, et al. Updated clinical considerations for dental implant therapy in irradiated head and neck cancer patients[J]. J Prosthodont, 2013, 22(6):432-438.
[28] Anderson L, Meraw S, Al-Hezaimi K, et al. The influence of radiation therapy on dental implantology[J]. Implant Dent, 2013, 22(1):31-38.
[29] Pace-Balzan A, Rogers SN. Dental rehabilitation after surgery for oral cancer[J]. Curr Opin Otolaryngol Head Neck Surg, 2012, 20(20):109-113.
[30] Javed F, Al-Hezaimi K, Al-Rasheed A, et al. Implant survival rate after oral cancer therapy: a review[J]. Oral Oncol, 2010, 46(12):854-859.
[31] Doğan GE, Halici Z, Karakus E, et al. Dose-dependent effect of radiation on resorbable blast material titanium implants: an experimental study in rabbits[J]. Acta Odontol Scand, 2017, 76(2):1-5.
[32] Brogniez V, D'Hoore W, Grégoire V, et al. Implants placed in an irradiated dog mandible: a morphometric analysis[J]. Int J Oral Maxillofac Implants, 2000, 15(4):511-518.
[33] Ocana RP, Rabelo GD, Sassi LM, et al. Implant osseointegration in irradiated bone: an experimental study[J]. J Periodontal Res, 2017, 52(3):505-511.