Comparison of n-HA/PLA/PVA Composite Membranes Prepared by 3D Printing with Different Weight Ratios

doi:10.13701/j.cnki.kqyxyj.2020.03.022

Abstract

Abstract: Objective: To prepare and test nano-hydroxyapatite/polylactic acid/polyvinyl alcohol (n-HA/PLA/PVA) composite membranes with different weight ratios. Methods: 3D printing technology was used to prepare n-HA/PLA/PVA composite membranes with different weight ratios, namely PLA/PVA composite membrane, 15% n-HA/PLA/PVA composite membrane, 50% n-HA/PLA/PVA composite membrane, and 75% n-HA/PLA/PVA composite membrane. The membrane morphology was observed with scanning electron microscope (SEM), the mechanical properties, cytotoxicity, and corresponding indices in animal experiments were detected. Results: SEM showed that the n-HA/PLA/PVA composite membrane exhibited a three-dimensional network structure, the materials were combined with each other, the distribution of pore was uneven, and the size was different. With the increase of the mass concentration of n-HA, the porosity between the materials was gradually reduced, and a composite membrane with uniform structure was formed. In the test of mechanical properties and water absorption, the tensile strength and water absorption of n-HA/PLA/PVA composite membranes decreased with the increase of n-HA. The cytotoxicity test showed no cytotoxicity and no significant difference in the cell proliferation rate of different proportions of composite membranes. It was found that there was no statistically difference in the ratios of n-HA/PLA/PVA composite membranes by measured periodontal plaque index and sulcus bleeding index in animal experiments. Conclusion: 3D printing n-HA/PLA/PVA composite membranes with different ratios have good physical properties and cell biocompatibility. Composite membranes with higher n-HA ratio may have better physical properties and biocompatibility.

Key words: 3D printing, nano-hydroxyapatite, polylactic acid, polyvinyl alcohol

QIAO Geng, LIU Jiayi, WANG Yuan, WANG Zhenhua. Comparison of n-HA/PLA/PVA Composite Membranes Prepared by 3D Printing with Different Weight Ratios[J]. Journal of Oral Science Research, 2020, 36(3): 280-286.

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