Abstract: Objective: To analyze the changes of laboratory parameters in patients with atrophic glossitis associated with VitB12 deficiency and to explore its correlation between clinical types and changes of laboratory parameters. Methods: 63 cases of atrophic glossitis with VitB12 deficiency were included from the Department of Oral Membrane Disease in our hospital from March 2016 to December 2019. According to the degree of atrophic tongue mucosa, they were divided into complete type and partial type. Changes in the levels of VitB12, folic acid, and erythrocyte parameters (red blood cells, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width) were observed and their correlation was further analyzed. Results: In the atrophic glossitis patients with VitB12 deficiency, the levels of VitB12, red blood cells, and hemoglobin decreased significantly, the levels of mean corpuscular volume and mean corpuscular hemoglobin increased significantly. The incidence of macrocytic anemia or macrocytosis in patients with complete type was higher than that of partial type (P<0.05). There was no significant difference in the parameter levels of folic acid, mean corpuscular hemoglobin concentration, and red blood cell distribution width between complete type and partial type. Overall analysis showed that the VitB12 level was positively correlated with red blood cells and hemoglobin levels in 63 patients with VitB12 deficiency glossitis, while the VitB12 level was negatively correlated with mean corpuscular volume and mean corpuscular hemoglobin concentration levels. Conclusion: The degree of tongue mucosa atrophy in patients with atrophic glossitis associated with VitB12 deficiency is not only closely related to the degree of VitB12 deficiency, but also closely related to macrocytic anemia or macrocytosis. Atrophic glossitis is one of the important signs of systemic diseases such as VitB12 deficiency and macrocytic anemia.

Key words: atrophic glossitis, Vitamin B12, folic acid, erythrocyte related parameter, macrocytic anemia