Journal of Oral Science Research

Journal of Oral Science Research ›› 2020, Vol. 36 ›› Issue (11): 1045-1049.DOI: 10.13701/j.cnki.kqyxyj.2020.11.014

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Efficacy of Compound Chamomile and Lidocaine in the Treatment of Oral Ulcer and Associated Pharmacological Mechanisms

CHENG Yingjie1,2,3, GAO Xin1,2,3, WANG Yuanyuan1,2, XU Lixian1,4, GU Yi1,5, WANG Xinwen1,2*   

  1. 1. State Key Laboratory of Millitary Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Xi'an 710032, China;
    2. Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an 710032, China;
    3. School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China;
    4. Department of Anesthesiology, Fourth Military Medical University, Xi'an 710032, China;
    5. Department of Pharmacy, Fourth Military Medical University, Xi'an 710032, China
  • Received:2020-03-06 Online:2020-11-28 Published:2020-11-27

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Abstract: Objective: To evaluate the efficacy of Compound Chamomile and Lidocaine (CCL) in the treatment of oral ulcer, and to investigate the potential mechanisms. Methods: Oral ulcers were induced in New Zealand rabbits by chemical cauterization. CCL and bFGF were applied respectively on ulcers three times per day. The ulcer area was measured at baseline, day 1, day 3, day 5, and day 7. The expressing levels of IL-8, TNF-α, and SOD were determined by immunohistochemistry. The antibacterial activities of CCL were assessed in vitro by bacteria inhibition ring test. Results: CCL could not promote the healing of oral ulcer compared with the control. Histological staining demonstrated that a large number of inflammatory cells still existed in the connective tissue of CCL group at day 7, however, the expressions of IL-8 and SOD were obviously down-regulated (P＜0.05), which was similar to that in the bFGF group. As to TNF-α expression, there was no significantly difference between the CCL group and other groups. CCL showed a strong activity in bacteria inhibition ring test, which was comparable to aureomycin. Conclusion: Besides the definite analgesic effect, reducing the expression of inflammatory cytokines and inhibiting the local infection may be the main mechanisms for CCL to play its clinical therapeutic role.

Key words: oral ulcer, oral ulcer healing, compound chamomile and lidocaine, antibacterial activity