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28 November 2020, Volume 36 Issue 11 Previous Issue    Next Issue

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Brief Probe into the Establishment of Management System of Specialist Training in Oral Maxillofacial Surgery HE Yue 2020, 36(11): 987-991.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.001 Abstract ( 259 )   PDF (1056KB) ( 303 )   Specialist training started relatively late in our country, especially for oral maxillofacial surgery, of which initial priority was conducted in several attached hospitals with imperfect training and management system. Oral maxillofacial surgery in our country is different from that in developed countries characterized by the more extensive spectrum of diagnosis and therapy, distinctive Chinese feature, which is also called "Oral Maxillofacial of Chinese Style". Although regulations of specialist training in developed countries could provide us reference in some extent, it is still urgent for us to establish the rules of specialist training suitable for our country. Excellent management system is good guarantee for the well conduction of specialist training. In current paper, we aim to elucidate how to establish the management system of specialist training with regard to oral maxillofacial surgery based on the experience of the developed countries. References | Related Articles | Metrics

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Research Progress of MicroRNA-155 in Regulating Bone Metabolism ZHANG Chengxiaoxue, ZHAO Qing 2020, 36(11): 992-995.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.002 Abstract ( 253 )   PDF (808KB) ( 195 )   Normal bone metabolism depends on a delicate balance between bone formation and bone resorption, which leads to a variety of bone-related diseases after break. As post-transcriptional factors, microRNAs are involved in the control of bone metabolism. Abnormalities in the function of microRNAs can also cause pathological changes in osseous tissue. As a potential target for the treatment of bone-related diseases, it has considerable application prospects in future clinical treatment. MicroRNA-155 is one of the most studied microRNAs, and its role in regulating bone metabolism has gradually been illustrated. This article reviews the concrete mechanism of microRNA-155 in regulating bone metabolism. References | Related Articles | Metrics

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Advancements of Bacteriology of Parotitis LI Changyi, ZHENG Lingyan 2020, 36(11): 996-999.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.003 Abstract ( 347 )   PDF (791KB) ( 424 )   Bacterial infection is the most common cause of parotid inflammation. In the past, most of the microbiology research of parotitis was focused on the bacterial culture of the pus from parotid suppurative infection. However, the microbiology of chronic parotitis has rarely been reported. With the development of detection technology, various types of aerobic and anaerobic bacteria have been found associated with parotitis. This paper describes the recent study of microbiology of parotitis and the application of molecular biology techniques in the study of oral microbes. References | Related Articles | Metrics

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Application of Graphene Oxide in Surface Modification of Titanium Implants ZHAO Wendi, LIU Xiaoqiu 2020, 36(11): 1000-1003.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.004 Abstract ( 265 )   PDF (795KB) ( 460 )   Titanium is widely used as dental implant and orthopedic implant due to its excellent physical and chemical properties and good biocompatibility. However, graft integration failure or implant centered infection may occur with titanium implants. In recent years, physical, chemical, and biological modifications of titanium surface for optimizing implant properties have become a research focus. Graphene oxide has good mechanical properties, bone conductivity, bone inductivity, biocompatibility, antibacterial property, and easy functionalization. At present, graphene oxide is increasingly applied in the research and development of composite biological materials. In this paper, the application of graphene oxide to surface modification of titanium is reviewed. References | Related Articles | Metrics

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Comparative Analysis of Recipient Veins in Reconstruction of Head and Neck Defects. YIN Shoucheng, XU Zhongfei 2020, 36(11): 1004-1006.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.005 Abstract ( 165 )   PDF (776KB) ( 211 )   Surgical removal of tumors of the head and neck usually results in tissue defect and dysfunction, the same as trauma and other factors. Therefore, it is very important to reconstruct the anatomical shape and physiological function of the head and neck tissue defect at the same time of surgical treatment. Microvascular free skin flap transplantation has become the main method for repairing head and neck tissue defects. Selecting suitable recipient vessels is the key factor to ensure the success of free skin flap transplantation. The recipient veins of head and neck for surgeons to choose include common facial vein, lingual vein, superior thyroid vein, transverse jugular vein, superficial temporal vein, external jugular vein, and internal jugular vein. At present, venous thrombosis is the main reason for the failure of free skin flap reconstruction, so it is very important to select the appropriate recipient vein. In this paper, the factors affecting venous selection in the reconstruction of head and neck defects are reviewed to provide evidence for clinical selection and further research. References | Related Articles | Metrics

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Advanced Glycation End Products Increase Inflammation via TLR4 Pathway in Periodontal Ligament Fibroblasts ZHANG Xun, YUAN Caixia, LIN Yuanyuan, TIAN Qunli 2020, 36(11): 1007-1011.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.006 Abstract ( 279 )   PDF (2469KB) ( 219 )   Objective: To investigate the effect of advanced glycation end products (AGEs),a product of diabetes,on the expression of Toll-like receptor 4 (TLR4)-mediated inflammation in periodontal ligament cells (PDLC). Methods: Different doses of AGEs (0,100,300,500 mg/L) were used to treat PDLCs. α-Actin was stained by immunofluorescence staining to detect the cytoskeleton. Western blot was used to detect the effect of AGEs on the expression of TLR4 and the downstream factors IL-1β and TNF-α,as well as the blocking effect of AGEs inhibitor E5564 on TLR4 activation. Immunofluorescence confirmed the activation of IL-1β and TNF-αvia TLR4 pathway by AGEs. Results: AGEs had no effect on the culture and morphology of PDLCs, and no significant effect on the expression of cell structural protein α-Actin. 300 mg/L and 500 mg/L AGEs significantly increased the TLR4 expression compared with the control group,and no statistical difference was found between the 300 mg/L and 500 mg/L doses. The activation of TLR4 caused by AGEs continued to lead to the up-regulation of IL-1β and TNF-α. Western blot and immunofluorescence proved that the addition of TLR4-specific inhibitor E5564 could reverse the activation of IL-1β and TNF-α induced by TLR4 pathway. Conclusion: AGEs have no obvious effect on the morphology of fibroblasts. AGEs may promote the release of inflammatory factors IL-1β and TNF-α from periodontal fibroblasts through the TLR4 pathway. References | Related Articles | Metrics

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Effect of Slightly Acidic Electrolyzed Water on Oral Flora in Patients with Periodontitis by 16S rDNA Sequencing Analysis CAO Cheng, LI Ping, HU Zhenqing, LI Ziliang 2020, 36(11): 1012-1015.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.007 Abstract ( 209 )   PDF (936KB) ( 510 )   Objective: To investigate the effect of slightly acidic electrolyzed water (SAEW) gargle on oral flora in patients with periodontitis. Methods: The saliva samples gargled with slightly acidic electrolyzed water of 10 patients with periodontitis who entered the supportive periodontal therapy were collected before and after 7 days. The total DNA of oral flora was extracted and sequenced by 16S rDNA sequencing, and the changes of oral flora diversity and structure were analyzed. Results: After gargled with slightly acidic electrolyzed water for 7 days, at phylum level, the relative abundance of proteobacteria, bacteroidetes and fusobacteria species was decreased. At the genus level, the relative abundance of periodontal pathogen genera-neisseria, porphyromonas, clostridium, and pretenella was decreased. Analysis of α-diversity: the Simpson index and Shannon index increased (P<0.05), Chao1 index, ACE index, and PD_whole_tree index were all increased (P<0.01). The analysis of the β-diversity index showed significant differences between the groups (P<0.01). Conclusion: The use of slightly acidic electrolyzed water can change the structure of oral flora and increase the abundance and diversity of oral flora in patients with periodontitis, which is conducive to the restoration of oral flora to the normal range. References | Related Articles | Metrics

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Analysis on Formation Mechanism of Oral Microbiome Diversity Induced by Delayed Response DONG Chen, HU Dawei 2020, 36(11): 1016-1021.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.008 Abstract ( 192 )   PDF (2800KB) ( 181 )   Objective: To explore the formation and maintenance mechanism of microorganisms in human oral cavity. Methods: Oral flora of 20 patients with oral health and disease were investigated, and the abundance of five common bacteria genera-Granulicatella, Porphyromonas, Corynebacterium, Leptotrichia, and Tannerella were analyzed. Results: Bacteria in the healthy mouth presented significant asynchronous fluctuation trend, while the fluctuation of bacteria in the mouth with disease is a stationary random process. The two basic response delays in the healthy mouth, i.e. reproductive delay and reaction delay, were identified, which were accompanied with interspecific delay and substrate decomposing delay. These delayed responses could cause asynchronous periodic fluctuations of the number of each species and thus form and maintain high species diversity. Based on the experimental data and hypothesis, an effective dynamic model of oral flora succession system was established. Conclusion: The effectiveness of the proposed oral microbiome succession mechanism was confirmed by a large number of simulation experiments. References | Related Articles | Metrics

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Effect of Site Preservation on Periodontal Status of Periodontal Patients GENG Shuangshuang, WANG Jian, YANG Li, FENG Xinxin, LU Lihua 2020, 36(11): 1022-1026.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.009 Abstract ( 250 )   PDF (802KB) ( 223 )   Objective: To explore the effect of site preservation on sulcus bleeding index (SBI), probing depth (PD), attachment loss (AL), and plaque index (PLI) in patients with periodontal disease. Methods: A total of 94 patients with periodontal disease who were treated in our hospital from February 2018 to January 2019 were selected. The patients were randomly divided into 2 groups, with 47 cases each. The control group underwent conventional implantation and restoration after tooth extraction, and the observation group underwent site preservation after tooth extraction. The implantation success rate, repair effect, SBI, PD, AL, PLI, and subjective evaluation results were compared between two groups of patients. Results: The implantation success rate of observation group was 100% (47/47), which was higher than that of control group (89.36%, 42/47, P<0.05). The total excellent and good rate in the observation group was 95.75%, which was higher than 82.98% in the control group (P<0.05). There was no significant difference in SBI, PD, AL, and PLI between two groups before treatment (P>0.05). After treatment, the SBI, PD, AL, and PLI in the two groups were significantly reduced (P<0.05), but the SBI and PLI were different after treatment. There was no statistical significance (P>0.05). PD and AL in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the masticatory function, appearance, and overall satisfaction of two groups were significantly improved, but the masticatory function, appearance, and overall satisfaction of the observation group were significantly higher than those of control group (P<0.05). Conclusion: Site preservation after extraction can significantly improve the success rate of implantation in patients with periodontal disease, improve the rate of excellent repair, reduce PD and AL, and improve patients' chewing function, appearance, and overall satisfaction References | Related Articles | Metrics

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Periodontal Healing of Maxillary Second Molar after Extraction of Impacted Third Molar LI Juan, ZHANG Dong, KANG Zhuangfei, ZHANG Ning, GU Jianqi 2020, 36(11): 1027-1030.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.010 Abstract ( 295 )   PDF (777KB) ( 317 )   Objective: To evaluate the change in the periodontal status of maxillary second molars after minimally invasive surgical extraction of asymptomatic adjacent impacted lower third molars. Methods: This prospective clinical study was conducted in 43 higher-risk periodontal impacted maxillary third molar. Plaque index, gingival index, and bleeding on probing and probing depth (PD) were recorded before surgery and at 3, 6, and 12 months after surgery at 5 sites on the distal aspect of the maxillary second molars. Results: The initial mean PD was (3.67±1.64) mm, with the deepest mean PD was at the distopalatal of the distal surface. At 12 months, a mean PD average of (2.12±0.70) mm was recorded, with a total average recovery of (1.55±1.47)mm (P＜0.05), that was higher at 3 months(1.46±1.45)mm (P＜0.05). The improvements of PD were statistically significant (P＜0.05) from baseline to 12-month follow-up and from the buccal to the distopalatal of the distal aspect of the maxillary second molars. The plaque index and gingival index of maxillary second molars were improved 12 months after surgery compared with those before surgery. Conclusion: Young adults with high-risk periodontal maxillary third molar impactions may benefit from early extraction. References | Related Articles | Metrics

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Excision of Submandibular Gland and Its Associated Wharton's Duct for Sialolithiasis Treatment GAO Ying, ZHANG Xiaomin, TIAN Chun, ZHANG Rui 2020, 36(11): 1031-1035.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.011 Abstract ( 185 )   PDF (1563KB) ( 218 )   Objective: To investigate the efficacy of excision of submandibular gland and its associated Wharton's duct in the treatment of sialolithiasis. Methods: A total of sixty patients with sialolithiasis underwent excision of submandibular gland via a transcervical incision combined with or without surgical resection of its associated Wharton's duct via an intraoral incision. The therapeutic effects and postoperative complications were evaluated. Results: Mean length of the resected Wharton's duct was significantly shorter in the traditional surgery group [(2.33±0.42) cm] than in the modified surgery group [(4.31±0.43) cm]. Ratio of sialoliths recurrence was significantly higher in the traditional surgery group (2/30) than in the modified surgery group (0/30). However, there was no significant difference in the postoperative complications such as lingual never damage, swallowing pain, hypoglossal gland cyst, chronic sublinguitis, hypoglossal never injury, facial nerve injury, and inflammation of the residual Wharton's duct between two groups. Conclusion: Excision of the submandibular gland and its associated Wharton's duct was safe and feasible for the treatment of sialolithiasis, which may be applied as an option for the patients with high risk of sialoliths recurrence References | Related Articles | Metrics

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Comparative Analysis of Sternocleidomastoid Muscle Flap and Oral Repair Membrane in Postoperative Treatment of Benign Parotid Tumor TAO Boqiang, LIU Yingkun, LI Yuyang, MIN Fenghe, LIU Huimin,YANG Zhijing, LIU Weiwei 2020, 36(11): 1036-1039.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.012 Abstract ( 192 )   PDF (1905KB) ( 148 )   Objective: To compare the clinical effects of sternocleidomastoid muscle flap and oral repair membrane in the repair of facial sunken deformities and the prevention of Frey syndrome after parotid surgery. Methods: Eighty patients with benign tumor of parotid gland, which were carried out in the Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University were randomly divided into three groups: skin flap group, repair membrane group, and control group. The skin flap group was repaired with sternocleidomastoid muscle flap on the basis of parotid surgery, the repair membrane group was filled with oral repair membrane on the basis of parotid surgery, and the control group received normal parotid surgery without other treatments. The patients were followed up 72 hours and 6 months after operation, and the differences of facial depression deformity, Frey syndrome, and neck-shoulder dyskinesia were observed. Results: The facial depression deformity in the skin flap group was better than those in the repair membrane group and the control group (P<0.05). Compared with the control group, the flap group and the repaired membrane group could effectively prevent the occurrence of Frey syndrome, and the flap group had better preventive effect (P<0.05). In this experiment, there was no accessory nerve injury in the skin flap group. Conclusion: Sternocleidomastoid muscle flap has better repair and preventive effect than oral repair membrane in postoperative parotid benign tumor, which is worth popularizing and applying in clinic. References | Related Articles | Metrics

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Research on Animal Experiments of Robotic System in Mandibular Reconstruction with Fibular WANG Xingtao, LIU Caihua, LV Yuxiang, JIN Le, LIU Xiaojing 2020, 36(11): 1040-1044.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.013 Abstract ( 186 )   PDF (4598KB) ( 200 )   Objective: To evaluate the effect of robot-assisted surgery through animal experiments of robotic system assisted mandibular reconstruction surgery. Methods: The animal experiments were conducted using the goat as the experimental subjects, including robotic system assisted surgery, computer navigation assisted surgery, and manual operation surgery. The mean error value between postoperative and preoperative models was calculated. The results of three experiments were compared and analyzed to verify the effectiveness of robot-assisted surgery. Results: The robotic system run stably and reliably during the surgery, and the postoperative accuracy was better than other experiments, which met the needs of mandibular reconstruction surgery. Conclusion: In the mandibular reconstruction surgery, the robotic system can assist surgeons to accurately position and stably hold the free bones to improve the operating precision and surgical quality. References | Related Articles | Metrics

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Efficacy of Compound Chamomile and Lidocaine in the Treatment of Oral Ulcer and Associated Pharmacological Mechanisms CHENG Yingjie, GAO Xin, WANG Yuanyuan, XU Lixian, GU Yi, WANG Xinwen 2020, 36(11): 1045-1049.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.014 Abstract ( 211 )   PDF (6734KB) ( 287 )   Objective: To evaluate the efficacy of Compound Chamomile and Lidocaine (CCL) in the treatment of oral ulcer, and to investigate the potential mechanisms. Methods: Oral ulcers were induced in New Zealand rabbits by chemical cauterization. CCL and bFGF were applied respectively on ulcers three times per day. The ulcer area was measured at baseline, day 1, day 3, day 5, and day 7. The expressing levels of IL-8, TNF-α, and SOD were determined by immunohistochemistry. The antibacterial activities of CCL were assessed in vitro by bacteria inhibition ring test. Results: CCL could not promote the healing of oral ulcer compared with the control. Histological staining demonstrated that a large number of inflammatory cells still existed in the connective tissue of CCL group at day 7, however, the expressions of IL-8 and SOD were obviously down-regulated (P＜0.05), which was similar to that in the bFGF group. As to TNF-α expression, there was no significantly difference between the CCL group and other groups. CCL showed a strong activity in bacteria inhibition ring test, which was comparable to aureomycin. Conclusion: Besides the definite analgesic effect, reducing the expression of inflammatory cytokines and inhibiting the local infection may be the main mechanisms for CCL to play its clinical therapeutic role. References | Related Articles | Metrics

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Clinical Evaluation of Er:YAG Laser in Primary Caries Treatment WANG Junhui, WANG Zirui, ZHOU Zhifei, ZHANG Baize, GE Xin, CHEN Yujiang, DU Yang, WANG Xiaojing 2020, 36(11): 1050-1054.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.015 Abstract ( 305 )   PDF (795KB) ( 440 )   Objective: To investigate the perception and effect of Er: YAG laser in the treatment of deep caries of primary teeth. Methods: Children aged 3-6 years were divided into Er:YAG laser group and traditional group randomly, then removed the decay and filled. The pain feeling of children, satisfaction of parents, and clinical effect were evaluated. Results: The average age of 108 children was 5.16 ± 0.81 years old and 224 teeth were treated. The pain level and parents' satisfaction in Er:YAG laser group was significantly better than traditional group (P<0.05). The time of caries removing was not statistically significant compared with the traditional group. In terms of clinical efficacy, within 6 months, the success rate in the Er:YAG laser group was slightly higher than traditional group. With the extension of observation time, the success rate of both groups decreased. After 2 years, the success rate was significantly higher than that of traditional group (P<0.05). The main reason of failure was secondary caries (35.05%), followed by loss of fillings (29.90%). Conclusion: Er: YAG laser is effective in the treatment of deep caries of primary teeth, which can effectively reduce the pain of children and is worthy of clinical application. References | Related Articles | Metrics

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Effect of Pretreatment by Carbodiimide on Bonding Properties of Two Kinds of Etch-and-rinse Adhesives ZHENG Yuemei, YAN Guowei, ZHOU Kaixuan, CHEN Yue, XIE Cuiliu 2020, 36(11): 1055-1059.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.016 Abstract ( 189 )   PDF (2021KB) ( 287 )   Objective: To evaluate the effect of pretreatment by carbodiimide (EDC) on bonding properties of two kinds of etch-and-rinse adhesives to dentin. Methods: 64 human third molars were collected and randomly divided into 8 groups (n=8). Group S, Sa: Pretreatment + ethanol/water-based adhesive (EDC + SB2); Group S0, S0a: No pretreatment + ethanol/water-based adhesive (deionized water + SB2); Group P, Pa: Pretreatment + acetone-based adhesive (EDC + PB); Group P0, P0a: No pretreatment + acetone-based adhesive (deionized water + PB). Group Sa, S0a, Pa, and P0a were conducted thermocycling aging test. 6 specimens were randomly selected from each group to measure the shear bond strength and observe the fracture mode, and the remaining 2 specimens were used to observe the microstructure of the bonding interface under scanning electron microscope (SEM). Results: The shear bond strength of group S was higher than that of group P, group S was higher than group S0, group Sa was higher than group S0a, and group Pa was higher than group P0a (P<0.05). After aging treatment, the shear bond strength of each group decreased, and there were no significant differences between group S and Sa, and group P and Pa (P>0.05). The main effect of adhesives, EDC, and aging treatment alone was significant (P<0.05), but the effect of the second and third order interaction on shear bond strength were not significant (P>0.05). The main fracture was mixed fracture in the immediate groups and interface fracture in the aging groups. SEM observation showed that the hybrid layer was intact in the immediate groups. There were cracks in the hybrid layer in the aging groups, and the cracks were the most obvious in the S0a and P0a groups. Conclusion: EDC pretreatment can improve the immediate shear bond strength of SB2, maintain bonding durability for both SB2 and PB to some extent, and obtain a better microscopic bonding interface. References | Related Articles | Metrics

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Application of Composite Resin Nanoceramics in Massive Defects of Teenagers' First Permanent Molars WANG Ping, XIE Ling, ZHANG Songying, HU Die 2020, 36(11): 1060-1064.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.017 Abstract ( 245 )   PDF (1421KB) ( 505 )   Objective: To compare the clinical effect of filling with composite resin and LavaTM Ultimate composite resin nanoceramics inlay in repairing children first permanent molars with massive defects. Methods: The first permanent molars of 84 massive defects in 62 children treated in our hospital were randomly divided into two groups: group A was repaired with LavaTM Ultimate composite resin nanoceramics inlay under CAD/CAM, group B was repaired with composite resin and regularly followed up. The effect of the two groups was evaluated with reference to the modified FDI standard after 6 and 12 months, respectively. Results: Six months later, there was no significant difference between two groups (P>0.05). After 12 months, there were no significant differences in surface staining, margin staining, marginal adaptation, and postoperative sensitivity between two groups (P>0.05), but the effect of group A was superior to that of group B in comparison of surface luster, fractures, retention, recurrence of caries, erosion, and exfliation (P<0.05). Conclusion: For the first permanent molars with severe defects, the long-term effect of LavaTM Ultimate excellent-toughness porcelain is superior to resin in terms of fracture resistance, surface luster, and recurrence of caries, and is a good restorative material, which deserves to be vigorously promoted. References | Related Articles | Metrics

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Finite Element Analysis of Maxillary First Premolars Repaired with Different Onlay Materials WEI Zhenhui, SUN Heting, GAO Zhiyin, WANG Wei, ZHANG Jiao, ZHANG Peng, WANG Jinhai 2020, 36(11): 1065-1068.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.018 Abstract ( 280 )   PDF (1948KB) ( 431 )   Objective: To investigate the intensity and distribution of stress after the restoration of the first maxillary premolar with large defect by using four different materials. Methods: One normal and intact first maxillary premolar was collected. Through CBCT scanning technology, Mimics19.0, Hypermesh2017, and Ansys19.0 reverse engineering software, 3D finite element model of large defects was established. Gold alloy, zirconia, composite resin, and glass-ceramic were used to restore the defect in the form of onlay. The intensity and distribution of maximum principal stress of onlay and residual dental tissues were observed when loaded vertically and laterally. Results: For the remaining tooth tissues, the order of maximum principal stress of tooth enamel under vertical loading was: composite resin > glass-ceramic > zirconia = gold alloy, the order of maximum principal stress of tooth enamel under lateral loading was: composite resin > zirconia > gold alloy > glass-ceramic. For the repair materials, the order of maximum principal stress of the onlay under vertical loading was: gold alloy > zirconia > glass-ceramic > composite resin, the order of maximum principal stress of the onlay under the lateral loading was: zirconia > glass-ceramic > composite resin > gold alloy. Conclusion: For large defects of the first maxillary premolar, the first choice is glass-ceramic onlay, however, with recommendation to reduce the inclination of the tooth tip and provide occlusal adjustment. References | Related Articles | Metrics

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Regulation and Mechanism of SIRT1 on Osteogenic Differentiation of Periodontal Ligament Stem Cells Stimulated by Orthodontic Static Pressure ZUO Zhigang, LI Hongfa, WANG Yue, ZHENG Zhao, YANG Ziliang, LIU Shan, LIU Dayong 2020, 36(11): 1069-1073.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.019 Abstract ( 224 )   PDF (1439KB) ( 225 )   Objective: To study the effect and mechanism of SIRT1 on osteogenic differentiation of PDLSCs stimulated by orthodontic static pressure. Methods: Primary PDLSCs were cultured and the third generation of PDLSCs was divided into control group, orthodontic static pressure group, orthodontic static pressure+resveratrol group, and orthodontic static pressure+nicotinamide group. The expression of SIRT1, OCN, Runx2, acetylated NF-κB, FOXO1, acetylated FOXO1, and the contents of TNF-α, IL-6, and MCP-1 were measured. The mineralized nodules numbers of alizarin red staining after osteogenesis induction were detected. Results: Compared with the control group, the number of mineralized nodules and the expression of SIRT1, OCN, Runx2, and FOXO1 increased, the expression of acetylated NF-κB, acetylated FOXO1, and the contents of TNF-α, IL-6, and MCP-1 decreased in orthodontic static pressure group. Compared with orthodontic static pressure group, the number of mineralized nodules and the expression of SIRT1, OCN, Runx2, and FOXO1 increased; the expression of acetylated NF-κB, acetylated FOXO1, and the contents of TNF-α, IL-6, and MCP-1 decreased in orthodontic static pressure+resveratrol group; the number of mineralized nodules and the expression of SIRT1, OCN, Runx2, and FOXO1 decreased; the expression of acetylated NF-κB, acetylated FOXO1, and the contents of TNF-α, IL-6, and MCP-1 increased in orthodontic static pressure+nicotinamide group. Conclusion: SIRT1 plays an important role in the osteogenic differentiation of PDLSCs under the stimulation of orthodontic static pressure, and its possible molecular mechanism is to regulate the acetylation of NF-κB and FoxO1. References | Related Articles | Metrics

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Soft and Hard Tissue Changes in Adults with Skeletal Class Ⅲ Malocclusion Before and After Camouflage Therapy LIU Lingxia, GUAN Yuxin, WU Xiuping 2020, 36(11): 1074-1078.  DOI: 10.13701/j.cnki.kqyxyj.2020.11.020 Abstract ( 295 )   Objective: To explore the changes and the correlation between soft and hard tissue in adults with skeletal class Ⅲ malocclusion before and after non-extraction camouflage treatment. Methods: Lateral cephalometric radiographs of 20 adult's subjects with skeletal Class III malocclusions were selected. 18 items of hard tissue and 15 items of soft tissue were measured before and after treatment to compare the changes and the correlation between soft and hard tissue. Results: After treatment, the index of hard tissue: SNA, U1- SN, U1-VRL, and U1-HRL increased, while L1-VRL decreased. The difference was statistically significant (P<0.05). The index of soft tissues: Sn-VRL, A'-VRL, UL-VRL increased, while facial convexity angle and LL-VRL decreased (P<0.05). The distance measuring index of soft and hard tissue had different degree correlation in sagittal direction (P<0.05) . Conclusion: In Class Ⅲ malocclusions, the mandibular incisors were relatively retroclined, and the maxillary incisors were relatively proclined to compensate for skeletal dysplasia after non-extraction camouflage treatment. The soft tissue profile was improved, the upper lip moved forward, and the lower lip was retracted. There was a correlation between the changes of soft and hard tissue. References | Related Articles | Metrics