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28 November 2024, Volume 40 Issue 11 Previous Issue   

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Re-establishment of Soft Tissue Sealing in Treatment of Peri-implantitis WANG Haozhe, LI Lei 2024, 40(11): 945-949.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.001 Abstract ( 80 )   PDF (821KB) ( 66 )   Peri-implantitis is the primary factor leading to the failure of implant prosthesis, and stable and healthy soft tissue sealing around dental implant is imperative for the long-term prognosis. In this review, the difficulties in the soft tissue sealing re-establishment in the treatment of peri-implantitis and the main methods to promote the re-establishment are elaborated, providing a comprehensive understanding of the property and the treatment of peri-implantitis for dental clinicians. References | Related Articles | Metrics

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Accuracy and Application Status of Robotic-assisted Implant Surgery LUO Zhilin, CAO Yingguang 2024, 40(11): 950-955.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.002 Abstract ( 81 )   PDF (835KB) ( 56 )   Currently, dental implant surgery has emerged as the preferred treatment for patients with tooth loss. Precise implant placement ensures safety and plays a crucial role in achieving accurate restoration and long-term stability. In recent years, with rapid advancements in computer technology, implant surgery has undergone a gradual transformation towards digitization and modernization. Robotic-assisted implant surgery offers numerous advantages including minimally invasive procedures, enhanced precision, and improved stability, thereby providing personalized, efficient, and precise methods for optimal implant placement. This article aims to introduce the clinical applications, accuracy, and influencing factors of robotic-assisted implant surgery, offering valuable insights for its application in clinical practice. References | Related Articles | Metrics

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Research Progress of PKM2 in Odontogenic Keratocysts WANG Haojun, ZHA Guangyu 2024, 40(11): 956-959.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.003 Abstract ( 59 )   PDF (840KB) ( 33 )   The odontogenic keratocyst (OKC) is a developmental cyst that has high potential for invasiveness, easy recurrence, and multiple occurrences. Its energy metabolism pathway is mainly glycolysis. Pyruvate kinase M2 (PKM2) is a key driving factor of glycolysis and plays an important role in regulating the tumor metabolic microenvironment. The traditional Chinese medicine (TCM) has a long history of treating tumors with its unique theory of "steady-state" effect on the tumor immune microenvironment. This review will delve into the regulation of PKM2 in respect of odontogenic keratocysts, aiming to provide new ideas for the clinical treatment of OKC with traditional Chinese medicine. References | Related Articles | Metrics

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Biomechanical Effects of Clear Aligners with Different Palatal Edge Extension in Extraction Cases: A Three-dimensional Finite Element Study WANG Jiangting, CHEN Mei, ZHANG Ruijing, LIU Linyi, SHE Rui, WEN Xiujie 2024, 40(11): 960-966.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.004 Abstract ( 60 )   PDF (2720KB) ( 23 )   Objective: To investigate the displacement of dentition during retraction of anterior teeth under different palatal edge extension of clear aligners in extraction cases. Methods: A finite element model was constructed to analyze the characteristics of tooth movement and periodontal membrane stresses of clear aligners. The model was based on different palatal edge extension and classified into four cases: working condition 1: supergingival 1 mm, working condition 2: flanking gingival, working condition 3: extended 1 mm, and working condition 4: extended 2 mm. Results: Clear aligners therapy caused lingual tipping and extrusion of incisors, distal tipping of canines, and mesial tipping of posterior teeth in each group. With increasing palatal edge length, the degree of sagittal inclination was gradually decreased in central incisors and the lateral incisors were minimized at work condition 2. The distal tipping of the canine increased gradually, lingual tipping gradually decreased, and extrusion displacement increased in working conditions 1 to 3 and decreased in working condition 4. The medial tipping and intrusion of the second premolar initially increased and tended to decrease in condition 4. The mesial tipping and intrusion of the first molar were gradually increased. The Mises stresses exhibited the highest peak stresses in the apical region of the cusps. Conclusion: Clear aligners can be a roller coaster when retracting upper anterior teeth in extraction cases, extending the palatal edge can facilitate the bodily movement of incisal, but the canine distal tipping displacement increased. If the edge length exceeds 1mm, it can effectively prevent the canine lingual inclination and extrusion, and the second premolar medial inclination. However, there is a need of greater anchorage to support the first molar. References | Related Articles | Metrics

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Smile Aesthetic Outcomes of Infrazygomatic Crest Miniscrews in Patients with Skeletal Class Ⅱ Malocclusions ZHAO Jian, SHI Shuya, LI Chaoqun, LI Xin, HOU Deqiang 2024, 40(11): 967-971.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.005 Abstract ( 39 )   PDF (1270KB) ( 14 )   Objective: To explore the smile aesthetic outcomes of infrazygomatic crest miniscrews in patients with skeletal Class Ⅱ malocclusions. Methods: One hundred and three patients with skeletal Class Ⅱ malocclusions admitted to our hospital from January 2017 to January 2021 were selected and assigned into two groups according to the orthodontic treatment plans. Study group (n=52) received infrazygomatic crest miniscrews plus straight-wire appliance, while control group (n=51) was given facebow headgear plus straight-wire appliance. The overall therapeutic efficacy, treatment duration, cephalometric indices six months post-treatment, smile aesthetic effects, and complication rates were compared between the two groups. Results: There was no difference in the success rate of treatment between the two groups (P>0.05),and the treatment time of the study group (14.3±3.6) was lower than that of the control group (20.1±4.2) (P<0.05). There was a notable improvement in the angle formed between the long axis of upper central incisor and the lower central incisor (U1-L1), angle formed between the long axis of lower central incisor and the mandibular plane (L1-MP), angle between the long axis of the upper central incisor and the plane of the anterior skull base (U1-SN), point A-Nasion-point B (ANB) angle, maxillary central incisor adduction (U1-Ptm), maxillary molar distal movement (U6-SP), overjet (OJ), and overbite (OB) in both group after treatment. The amount of change in U6-SP was smaller and the amount of change in U1-L1, U1-SN, U1-Ptm and L1-MP was larger in study group than that in control group before and after orthodontic treatment (P<0.05). There was no statistical difference between two groups in the comparison of the complications such as root resorption, maxillary sinus floor infection, traumatic ulceration, and peri-implantitis (P>0.05). Conclusion: Application of infrazygomatic crest miniscrews in patients with skeletal Class Ⅱ malocclusions can effectively shorten the orthodontic time, improve the maxillary retraction of anterior teeth, and ameliorate the smile aesthetics. References | Related Articles | Metrics

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Effects of Maxillary Sinus on Molar Distalization with Clear Aligners HUANG Rongcai, ZHENG Quanyi, LONG Jinfeng, XIONG Guoping. 2024, 40(11): 972-977.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.006 Abstract ( 38 )   PDF (3415KB) ( 19 )   Objective: To study the relationship between maxillary sinus and root position of molars using cone-beam computed tomography (CBCT) and examine whether it affects the efficiency and bodily movement rate of molar distalization with clear aligners. Methods: This prospective study included 13 patients who used clear aligner techniques to push 45 maxillary molars backward. There were 18 molars whose roots were embedded in the maxillary snus (embedded group) and 27 molars whose roots were not (non-embedded group). Before orthodontic treatment and after the upper molars were moved back into position, CBCT was taken. Mimics software was used to overlap the maxilla and establish three-dimensional coordinates based on the occlusal plane. Changes in the distance, axial inclination, and torque angle of the molar distalization were measured. Results: The clear aligner technique could effectively move the maxillary molars in a distal direction. The effective rate of crown distal movement in the embedded group was 86.35%, and in the non-embedded group was 79.24%. The overall effective rate of root distal migration in the embedded group was 59.48%, and in the non-embedded group was 76.46%. The distally tipping angle of the embedded group was 2.43°, and that of the non-embedded group was 3.51°. The buccal tipping angle of the embedded group was 4.29°, and that of the non-embedded group was 3.28°. There was no statistically significant between two groups. Conclusion: The different relationship between maxillary sinus and molar root position has no significant effect on the efficiency and bodily movement rate of maxillary molar distalization. References | Related Articles | Metrics

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Effects of Triptolide on Periodontal Inflammation and Osteoclasts in Orthodontic Tooth Movement Model Rats through p38 MAPK/ERK/JNK Signaling Pathway CAI Yehua, LI Xing, ZHAO Yanxia, WANG Li, LI Hang 2024, 40(11): 978-984.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.007 Abstract ( 44 )   PDF (3845KB) ( 14 )   Objective: To explore the effects of triptolide on periodontal inflammation and osteoclasts in orthodontic tooth movement model rats through regulating p38 mitogen-activated protein kinase (p38 MAPK)/extracellular signal-regulated kinase (ERK)/c-Jun amino-terminal kinase (JNK) signaling pathway. Methods: The rat orthodontic tooth model was established and totally 48 rats were randomly equally divided into model group, triptolide low dose (50 μg/kg) group, high dose (100 μg/kg) group, and triptolide high dose (100 μg/kg) + p38 MAPK activator (25 μg) group. Twelve healthy rats were set as control group. Each group was given corresponding intervention methods for 2 weeks. The distance of orthodontic tooth movement was measured. Osteoclasts in periodontal tissue were stained with tartrate resistant acid phosphatase and counted. The expression of bone morphogenetic protein-2 (BMP-2) in periodontal tissue was detected with immunohistochemical staining. The serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), prostaglandin E2 (PGE2), osteoprotegerin (OPG), and receptor activator of nuclear factor-κB ligand (RANKL) were detected by enzyme linked immunosorbent assay. The expressions of p38 MAPK/ERK/JNK pathway related proteins in periodontal tissues were detected by western blot. Results: Compared with control group, the movement distance of orthodontic teeth, the number of osteoclasts in periodontal tissue, the expression intensity of BMP-2, the levels of serum TNF-α, IL-1β, PGE2, RANKL, phosphorylated (p)-p38 MAPK/p38 MAPK, p-ERK1/2/ERK1/2, and p-JNK/JNK protein ratio in the model group were significantly increased, however, the serum OPG level was significantly decreased (P<0.05). Compared with model group, the movement distance of orthodontic teeth, the expression intensity of BMP-2 in periodontal tissue, and the level of serum OPG in triptolide low dose and high dose groups were increased successively, the number of osteoclasts in periodontal tissue, serum TNF-α, IL-1β, PGE2, RANKL levels, p-p38 MAPK/p38 MAPK, p-ERK1/2/ERK1/2, and p-JNK /JNK protein ratio were decreased (P<0.05). p38 MAPK activator could reverse the effect of high dose triptolide on orthodontic tooth movement model rats (P<0.05). Conclusion: Triptolide can reduce periodontal inflammation, decrease the number of osteoclasts, improve bone resorption, and accelerate orthodontic tooth movement in orthodontic model rats. Its mechanism is related to the inhibition of p38 MAPK/ERK/JNK signaling pathway activation. References | Related Articles | Metrics

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Modified Electrospinning Three-dimensional Nanofiber Scaffold for Bone Repair GUAN Xinyue, LIU Yuhui, AN Xin, XU Bingxue, MENG Wenxin, ZHOU Ning, WU Guomin 2024, 40(11): 985-991.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.008 Abstract ( 37 )   PDF (4599KB) ( 17 )   Objective: To prepare three-dimensional nanofibrous scaffold by electrospinning and electrospraying technology, and to investigate its bone repair ability. Methods: The three-dimensional polycaprolactone scaffold (PCL NFs + PCL MSs) was prepared by alternating electrospinning/electrospraying. The morphology of the scaffold was observed by scanning electron microscope, and the mechanical properties were tested. Live/dead staining and cytoskeleton staining were performed to evaluate the biocompatibility of scaffold. The in vitro osteogenic performance of the scaffold was investigated using real-time quantitative PCR, alkaline phosphatase (ALP) staining, alizarin red staining (ARS), and immunofluorescence staining. Finally, the in vivo bone repair ability of the scaffold on rat skull defect model was evaluated. All experiments used pure electrospun nanofibrous scaffolds (PCL NFs) as controls. Results: PCL NFs + PCL MSs exhibited obvious nanofiber and microsphere structure. Compared to PCL NFs, PCL NFs + PCL MSs had better three-dimensional structure (nearly 3-fold increase in thickness), significantly improved mechanical properties, and biocompatibility. The cells were more easily ingrained into the interior of PCL NFs + PCL MSs. In vitro studies shown that the expression of osteogenic related genes [bone morphogenetic protein-2 (BMP2), alkaline phosphatase (ALP), collagen type Ⅰ (COL1), Runt-related transcription factor 2 (RUNX2), and osteopontin (OPN)] and proteins (COL1, BMP2) in bone marrow mesenchymal stem cells of PCL NFs + PCL MSs were significantly upregulated. ALP and ARS staining also suggested that PCL NFs + PCL MSs had better osteogenic ability. In vivo study indicated that PCL NFs + PCL MSs had significantly improved bone repair ability. Conclusion: The three-dimensional nanofiber scaffold was successfully prepared by alternating electrospinning and electrospraying. This scaffold has significantly improved bone repair performance and good clinical application prospects. References | Related Articles | Metrics

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SF/PCL/KAE Nanofibrous Scaffolds Promote Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells through Immune Microregulation LIU Yuhui, GUAN Xinyue, XU Bingxue, AN Xin, ZHOU Ning, MENG Wenxin, WU Guomin 2024, 40(11): 992-998.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.009 Abstract ( 31 )   PDF (5851KB) ( 20 )   Objective: To prepare silk fibroin/polycaprolactone/kaempferol nanofibrous scaffolds(SF/PCL/KAE)and evaluate their effect on RAW264.7 polarization, and to investigate the effect of immune microregulation on the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs). Methods: SF/PCL/KAE was prepared by electrospinning and characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction spectroscopy (XRD). Tensile mechanics properties and antibacterial properties were also evaluated. CCK-8 assay and SEM observation were performed to evaluate the cytocompatibility of the scaffolds. Lipopolysaccharide (LPS)-treated RAW264.7 was seeded on scaffolds, the reactive oxygen species (ROS) scavenge ability of the scaffold was detected, and the polarization of RAW264.7 and the expression of inflammation-related factors were detected by flow cytometry and RT-qPCR. Finally, BMSCs were co-cultured with LPS-treated RAW264.7, and RT-qPCR was used to detect the expression of genes related to osteogenic differentiation after 7 days of mineralization induction, and alkaline phosphatase (ALP) staining was performed on 7days and 14 days, respectively, and alizarin red staining (ARS) was performed 14 days later. Results: SEM, FTIR, and XRD results demonstrated good morphology of the nanofibrous scaffold and the successful introduction of KAE. Compared with SF/PCL, SF/PCL/KAE has better tensile mechanical properties and excellent antimicrobial ability to S.aureus(>99%) without obvious cytotoxicity. SF/PCL/KAE showed good ROS scavenging ability, inhibited the polarization of RAW264.7 to the M1 phenotype, and promoted its polarization to the M2 phenotype, and down-regulated the expression of tumor necrosis factor-α (TNF-α) and up-regulated the expression of CD206 and TGF-β1. In the inflammatory environment simulated by RAW264.7 treated with LPS, SF/PCL/KAE up-regulated the expression of ALP, collagen type Ⅰ (COL-1), bone morphogenetic protein-2 (BMP-2), and osteopontin (OPN), and ALP and ARS staining also confirmed that the introduction of KAE could promote the osteogenic differentiation of BMSCs. In the above studies, the 2% KAE showed better mechanical properties, antibacterial effects, and bone immune micromodulation properties than 1%KAE. Conclusion: SF/PCL/KAE has good mechanical properties, antibacterial properties, and bone immune micromodulation ability, which can significantly promote the osteogenic differentiation of BMSCs in inflammatory environment. References | Related Articles | Metrics

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Application of High Frequency Ultrasound in Diagnosis and Treatment of Mini-microform Cleft Lip YANG Xin, XIE Ying, LI Jian, YANG Xiaohong, ZHAO Sheng 2024, 40(11): 999-1003.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.010 Abstract ( 36 )   PDF (2351KB) ( 7 )   Objective: To investigate the value of high-frequency ultrasound in the diagnosis and treatment of mini-microform cleft lip. Methods: Based on the inclusion and exclusion criteria, data from 12 patients with mini-microform cleft lip were collected, in which 10 were males and 2 were females, with a mean age of 2.6 years. All patients took frontal photographs and underwent high-frequency ultrasonography prior to surgery. Indicators, such as the thickness of subcutaneous connective tissue and the superficial layer of the orbicularis oris muscle, the deep layer of the orbicularis oris muscle, and the thickness and angle of the cross fiber bundles of the orbicularis oris muscle, were measured and evaluated. Results: High-frequency ultrasound revealed the depression of red lip and midface ridge. Irregular low echoes were seen in the superficial orbicularis oris muscle and subcutaneous connective tissue layer of upper lip on the affected side. The thickness of superficial orbicularis oris muscle layer was significantly thinner than that of the healthy side (P=0.002). No significant abnormal echoes were seen in the deep orbicularis oris muscle and connective tissue. The angle between the crossed fiber bundles of the orbicularis oris muscle and the horizontal reference line was greater on the affected side than on the healthy side (P<0.001). Conclusion: High-frequency ultrasonography can visualize the abnormalities of subcutaneous connective tissue of the upper lip and the orbicularis oris muscle in patients with very mini-microform cleft lip, and the findings can aid in the development of personalized treatment plan. References | Related Articles | Metrics

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Application of Fiberoptic Endoscopic on Evaluation of Swallowing Function in Patients with Tumors Involving Both Oral Tongue and Base of Tongue ZHU Yue, QIAN Xiaoyun, HENG Weiwei, SUN Guowen 2024, 40(11): 1004-1008.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.011 Abstract ( 36 )   PDF (1118KB) ( 6 )   Objective: To investigate the clinical application of fiberoptic endoscopic on evaluation of swallowing (FEES) and the recovery of swallowing function in patients with lesions involving both the oral tongue and the base of the tongue (OBOT). Methods: Patients diagnosed with OBOT lesions between April 2022 and May 2023 underwent assessments preoperative and at 1 week, 1 month, and 1 year after surgery. The evaluation of swallowing function included the MD Anderson Dysphagia Inventory (MDADI), University of Washington Quality-of-Life Questionnaire, Performance Status Scale for Head and Neck Cancer, water swallow test, tongue motion measurement, and FEES (Penetration-Aspiration Scale, oropharyngeal swallowing efficiency). The reliability of the evaluation of OBOT by FEES was statistical analyzed. Results: In total, 21 patients participated in this study. FEES had high diagnostic value (area under the curve=0.916). FEES parameters were significantly correlated with the results of the water swallow test and MDADI scores (all P<0.001). The swallowing function of patients with OBOT lesions returned to the preoperative level at 1 year postoperatively, but the oropharyngeal swallowing efficiency decreased significantly, and the quality of life was still affected (all P<0.001). Conclusion: FEES is a reliable method for evaluating the postoperative swallowing function of patients with OBOT lesions and is worthy of clinical promotion. In postoperative review, although the swallowing function of these patients was restored, attention should be paid to the swallowing efficiency and quality of life. References | Related Articles | Metrics

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Clinical Comparative Research of Forearm Dermal Fat Flap for Reconstruction of Defects in Oral and Maxillofacial Region SUN Libo, LAN Yuyan, ZHANG Lei, SUN Xiaoqiang, ZHANG Chunfeng, WANG Changmi, LIANG Yunhong 2024, 40(11): 1009-1012.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.012 Abstract ( 39 )   PDF (1324KB) ( 15 )   Objective: To evaluate the applicable effect of forearm dermal fat flap in the repair of defects in oral and maxillofacial region. Methods: From July 2020 to June 2023, 24 patients with soft tissue defects in oral and maxillofacial region were repaired with forearm flap. According to the method of operation criteria, 24 patients were divided into traditional forearm flap group (12 cases) and forearm dermal fat flap group (12 cases). The flap preparation time, flap size, and the appearance and function of the forearm donor site at 6 months post-operatively were evaluated. Results: The flap survival rates of both groups were 100%. The flap preparation time of traditional forearm flap group was shorter than that of the forearm dermal fat flap group (P<0.05), and there was no difference in the flap size between two groups (P>0.05). Six months after the surgery, there was significant difference in the pigment deposition and surgical scars in the donor area between two groups (P<0.05), however, no significant difference in hand sensation and wrist movement (P>0.05). Conclusion: There was no difference in the functional recovery of the donor site between two groups of patients. The forearm dermal fat flap avoided the third surgical site and had little impact on the appearance of the donor site, which provided an alternative to the conventional forearm flap harvest. References | Related Articles | Metrics

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Clinicopathological Factors and Biomarker Immunoprofile Affecting Prognosis of Salivary Ductal Carcinoma. BAO Luri, SHI Lin 2024, 40(11): 1013-1018.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.013 Abstract ( 38 )   PDF (6928KB) ( 6 )   Objective: To explore the clinicopathological factors and biomarker immunoprofile affecting the prognosis of salivary ductal carcinoma. Methods: Retrospective analysis was applied on 23 cases of salivary ductal carcinoma including follow-up record and other clinical data collected. HE staining, immunohistochemical MaxVision two-step staining, and HER2 (HER2/Neu) gene amplification investigated by SISH were performed. Overall survival (OS) were analyzed with Kaplan-Meier curves and Cox regression. Results: Twenty-one were males and 2 were females, with an average age of 63.91 years old (39-86 years old). Tumors occurred in the parotid gland (15 cases) and submandibular gland (8 cases). Follow-up revealed 4 cases of mortality and 4 cases of relapse, while the remaining patients were survival without recurrence after surgery. The mean follow-up time was 42 months. The tumor tissue appears as heterogeneous patterns including intraductal cribriform, nest, solid, glandular tubular, and cord like structure. Acne-like necrosis was observed at the central area of the cribriform-like and solid structure. Tumor cells displayed large size, eosinophilic and granular cytoplasm, prominent and polymorphic nuclei, obvious nucleoli, dense chromatin, and visible mitotic figures. Immunophenotype was CK7 (23/23), AR (21/23), giant cystic disease liquid protein (GCDFP-15) (17/23), p53 (16/23), CK5/6 (11/23), HER2 (10/23), GATA3 (10/23), CK14 (3/23), and p63 (2/23). S-100 was not expressed. Ki-67 proliferation index ranged from 5% to 80%. CK5/6-positive cases were more often diagnosed at tumor stage Ⅲ/Ⅳ (P=0.009), while AR, HER2, GATA3, and Ki-67 proliferation indices were not related to the clinicopathological characteristics of patients (P>0.05). Univariate and multivariate survival analyses showed that clinical staging was a risk factor for OS in patients (P=0.042). Conclusion: Salivary ductal carcinoma is highly invasive, prone to recurrence and metastasis. CK5/6-positive is a potential biomarker of poor outcome in SDC. References | Related Articles | Metrics

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Osteonecrosis of Maxillary Bone Caused by Invasive Fungal Disease of Oral and Maxillofacial Region: A Case Report KOU Jiahao, CHEN Zhenxing, LI Zihui, LI Ke, ZHAO Kai, SUN Guowen 2024, 40(11): 1019-1021.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.014 Abstract ( 44 )   PDF (2664KB) ( 21 )   Fungal osteomyelitis in the oral and maxillofacial region is extremely rare in clinical, whose diagnosis is very difficult. Due to the lack of characteristic clinical manifestations and test results, it often leads to misdiagnosis, delays treatment, and even endangers life. This paper reports the combined diagnosis and treatment of a case of maxillary osteomyelitis caused by fungal infection. The etiology, clinical manifestations, diagnosis, and treatment plan were discussed. References | Related Articles | Metrics

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Solitary Neurofibroma of Lower Lip: A Case Report LIU Peicai, ZHANG Shuai, LI Zhangyi 2024, 40(11): 1022-1024.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.015 Abstract ( 43 )   PDF (3895KB) ( 35 )   Solitary neurofibroma (SNF) is a rare occurrence in oral cavity, with extremely rare occurrence in lip. This article reports a case of SNF in the lower lip and reviews relevant literature to discuss the clinical manifestations, diagnosis, and treatment of SNF in the lip, so as to provide reference for clinical diagnosis and follow-up studies. References | Related Articles | Metrics

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Peripheral Ossifying Fibroma: A Case Report TANG Yanchi, GE Diankui 2024, 40(11): 1025-1027.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.016 Abstract ( 46 )   PDF (2271KB) ( 39 )   Peripheral ossifying fibroma is clinically rare and mainly affects gingival tissue. This article reports a case of pathologically confirmed peripheral ossifying fibroma of the left mandibular lingual gingiva. After completely surgical resection, pathological examination confirms the diagnosis. This article discusses the disease through literature review. References | Related Articles | Metrics

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Oral Candidiasis Induced by Secukinumab: A Case Report LI Zhijun, LU Rui 2024, 40(11): 1028-1031.  DOI: 10.13701/j.cnki.kqyxyj.2024.11.017 Abstract ( 52 )   PDF (3287KB) ( 20 )   Oral candidiasis is a common fungal infectious disease of the oral mucosa, which is more often seen in people with reduced defenses due to various factors. With the wide application of broad-spectrum antibiotics, glucocorticoids, and the development of novel immunomodulatory agents and biologics, iatrogenic oral candidiasis caused by medicine usage is increasing recently. In the diagnosis and treatment of oral candidiasis, controlling the predisposing factors is the key to achieving good therapeutic effect, so it is important to clarify the predisposing factors of the disease for the standardized diagnosis and treatment. Here we reports a case of oral candidiasis induced by the use of secukinumab for the treatment of psoriasis, aiming to provide reference for clinical understanding of new causes of oral candidiasis and formulating corresponding treatment strategies. References | Related Articles | Metrics