Role and Mechanisms of Macrophage-mediated Osteoimmunity in Osseointegration after Implant Placement

doi:10.13701/j.cnki.kqyxyj.2025.03.003

Abstract

Abstract: The key to successful implant therapy is the formation of good osseointegration between the implant and the alveolar bone. Macrophage plasticity, however, plays a key role in all stages of osteogenesis and healing, and is involved in osseointegration after implant placement. Currently, the mechanisms behind macrophage plasticity are unclear, and further exploration of the interactions between immune cells and between them and macrophages is needed to search for targets of polarization reversibility. In this review, by summarizing macrophage origin, classification, polarization plasticity, and function, their role in regulating bone immunity after implant placement is concluded and the mechanism of osseointegration after implant placement from the osteoimmune level is elaborated, which will provide a theoretical basis for the design of implants with good osteoimmune effects, thus reducing the risk of implant placement failure.

Key words: macrophages, osteoimmunology, osseointegration, implants, immunomodulation

LI Congcong, ZHAO Li. Role and Mechanisms of Macrophage-mediated Osteoimmunity in Osseointegration after Implant Placement[J]. Journal of Oral Science Research, 2025, 41(3): 189-194.

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