Differential Expression Profiles of miRNAs in Blood of Periodontitis Patients.

doi:10.13701/j.cnki.kqyxyj.2021.10.007

Abstract

Abstract: Objective: To characterize the microRNA (miRNA) profiles in blood of periodontitis patients. Methods: One miRNA expression profile (GSE61741) was downloaded from the GEO database and analyzed using GEO2R. Logistic regression analysis was used to screen independent variables among differentially expressed miRNAs (DE-miRNAs). The diagnostic values of screened miRNAs were determined by the area under the receiver operating characteristic (ROC) curve (AUC). Results: A total of 232 DE-miRNAs, consisting of 109 upregulated DE-miRNAs and 123 downregulated DE-miRNA, were screened. Logistic regression analysis showed that there were three miRNAs related to periodontitis, namely hsa-mir-361-5p, hsa-mir-663, and hsa-mir-744. The AUC values of hsa-mir-361-5p, hsa-mir-663, hsa-mir-744, and their combination in the diagnosis of periodontitis were 0.871, 0.899, 0.925, and 0.981, respectively (P<0.01). Conclusion: MiRNAs are expressed differentially in periodontitis patients. hsa-mir-361-5p, hsa-mir-744, and hsa-mir-663 were associated with the risk of periodontitis and had potential value in the diagnosis of periodontitis.

Key words: periodontitis, microRNA, incidence risk, diagnosis

ZHANG Zheng, ZHENG Youli, BIAN Xiaowei. Differential Expression Profiles of miRNAs in Blood of Periodontitis Patients.[J]. Journal of Oral Science Research, 2021, 37(10): 894-899.

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