Study on Triclosan in Improving the Antibacterial Properties of Resin Cement

doi:10.13701/j.cnki.kqyxyj.2023.05.009

Abstract

Abstract: Objective: To prepare antibacterial resin cement containing photocurable triclosan derivative, and to evaluate its characterization performance, mechanical properties, adhesive strength, antibacterial properties, and cytotoxicity in vitro. Methods: The photocurable triclosan derivative (TCS-IH) was dissolved in acetone at 25 wt% and then added to Multilink Speed at a mass ratio of 0 wt%, 2 wt%, 4 wt%, 6 wt%, and 8 wt%, to obtain the resin cement with antibacterial properties for different components. FTIR was used to examine the conversion of double bonds before and after curing of resin cement in each group. The surface wettability of resin cement in each group was examined by static water contact angle. Its flexure strength was tested with a three-point bending test. Micro-tensile test was used to examine its instant bonding properties. S.mutans was selected for antibacterial experiments, and the antibacterial properties of resin cements were evaluated by colony counting, MTT, and live/dead bacterial fluorescence staining. The cytotoxicity grade in vitro was evaluated by CCK-8 cytotoxicity assay. Results: The addition of TCS-IH acetone solution at 2 wt% and 4 wt% had no significant effect on characterization performance, mechanical properties, and bonding strength of resin cement (P>0.05). When the mass percentage of TCS-IH reached 4 wt%, 6 wt%, and 8 wt%, resin cement all showed significant antimicrobial activity (P<0.05). Both 2 wt% and 4 wt% resin cements had good biocompatibility. Conclusion: When the mass percentage of TCS-IH was 4 wt%, the antibacterial properties of resin cement were effectively improved while its characterization properties, mechanical properties, adhesive properties, and biosafety were not affected.

Key words: resin cement, self bonding, photocurable triclosan derivative, antibacterial properties, adhesion property

HOU Yanyan, CHEN Huan, FENG Shanshan, DING Jingyu, ZHU Song. Study on Triclosan in Improving the Antibacterial Properties of Resin Cement[J]. Journal of Oral Science Research, 2023, 39(5): 422-428.

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