Research Progress of Metal Ion Doped Silicocarnotite Bioceramics in Field of Bone Repair

doi:10.13701/j.cnki.kqyxyj.2023.10.004

Abstract

Abstract: Oral hard tissue defects caused by periodontal diseases, tumors, trauma, and congenital malformations bring great difficulties to the reconstruction of oral function. Silicocarnotite [Ca₅(PO₄)₂SiO₄,CPS] bioceramics have become the research hotspot of new generation of bone defects restoration materials due to their good biocompatibility, degradability, osteoconductivity, and bone conductivity. Natural human mineralized tissues contain various metal ions such as Cu²⁺, Fe³⁺, Zn²⁺, Mg²⁺, Sr²⁺, etc, which have their unique biological properties, and the incorporation of these metal ions into silicocarnotite has great potential for material modification. This paper outlines the current investigations of silicocarnotite bioceramics, focusing on the effects of ion doping on the physicochemical properties of bioceramics, the role of metal ions in antibiosis and promoting osteogenesis and neoangiogenesis, and their possible mechanisms, and provides an outlook on the future development of silicocarnotite-based materials.

Key words: silicocarnotite, ion doping, bioceramics, bone tissue repair

LI Xinrui, MENG Weiyan. Research Progress of Metal Ion Doped Silicocarnotite Bioceramics in Field of Bone Repair[J]. Journal of Oral Science Research, 2023, 39(10): 871-874.

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