Dynamic Monitoring of Oral Lichen Planus with Epithelial Dysplasia and Effect of Photodynamic Therapy Using DNA Content Analysis of Exfoliated Cells: A Case Report

doi:10.13701/j.cnki.kqyxyj.2024.04.018

Abstract

Abstract: Oral lichen planus (OLP) is a common chronic inflammatory oral mucosal disease with a risk of malignant transformation, which required active intervention and close follow-up and monitoring. Photodynamic therapy (PDT) has been widely used in the treatment of OLP due to its advantages of minimally invasive, effective, good selectivity, and repeatability. However, there are still limitations in the efficacy evaluation approaches of PDT for OLP. DNA quantitative analysis of exfoliated cells is a non-invasive auxiliary examination method, which can be used for the early screening and diagnosis of the malignancy of oral potentially malignant disorders and oral cancer. Here we reported a case of OLP with epithelial dysplasia using DNA content analysis of exfoliated cells to dynamically monitor the risk of malignancy and the effect of PDT. The aim of this report is to provide a reference for establishing the precise and minimally invasive diagnosis and treatment of OLP with epithelial dysplasia.

Key words: DNA content analysis of exfoliated cells, oral lichen planus, epithelial dysplasia, photodynamic therapy

DONG Bingjie, LIU Zeyu, LI Ting, ZHOU Gang, LU Rui. Dynamic Monitoring of Oral Lichen Planus with Epithelial Dysplasia and Effect of Photodynamic Therapy Using DNA Content Analysis of Exfoliated Cells: A Case Report[J]. Journal of Oral Science Research, 2024, 40(4): 371-374.

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