Research Progress in Etiology and Pathogenesis of Hairy Tongue

doi:10.13701/j.cnki.kqyxyj.2024.09.001

Abstract

Abstract: Hairy tongue is a hairy lesion on the dorsal surface of the tongue that can be stained by food, tobacco, or microorganisms, resulting in a variety of colors such as white, tan, and black. Hairy tongue is a kind of benign lesions that can cause halitosis, dry mouth, aesthetic problems, so that patients’ quality of life is reduced. At present, the pathogenesis of hairy tongue has not been clarified. This review summarizes current studies on the etiology and pathogenesis of hairy tongue, which may be related to metabolic abnormality of filiform papillae, oral microbiota imbalance, immune abnormal phenomenon, and use of certain drugs.

Key words: hairy tongue, black hairy tongue, etiology, pathogenesis

WU Sihua, CHEN Qianming. Research Progress in Etiology and Pathogenesis of Hairy Tongue[J]. Journal of Oral Science Research, 2024, 40(9): 757-761.

References

[1] Bhattacharya PT, Sinha R, Pal S. Prevalence and subjective knowledge of tongue lesions in an Indian population [J]. J Oral Biol Craniofac Res, 2016, 6(2): 124-128.
[2] Zahid E, Bhatti O, Zahid MA, et al. Overview of common oral lesions [J]. Malays Fam Physician, 2022, 17(3): 9-21.
[3] Manabe M, Lim HW, Winzer M, et al. Architectural organization of filiform papillae in normal and black hairy tongue epithelium: dissection of differentiation pathways in a complex human epithelium according to their patterns of keratin expression [J]. Arch Dermatol, 1999, 135(2): 177-181.
[4] Harada Y, Gaafar H. Black hairy tongue: A scanning electron microscopic study [J]. J Laryngol Otol, 1977, 91(1): 91-96.
[5] Mangold AR, Torgerson RR, Rogers RS. Diseases of the tongue [J]. Clin Dermatol, 2016, 34(4): 458-469.
[6] Wang X, Yang S, Wang Y. Image Gallery: Black hairy tongue in a patient receiving enteral feeding [J]. Br J Dermatol, 2019, 181(4): e91.
[7] Schlager E, St Claire C, Ashack K, et al. Black hairy tongue: Predisposing factors, diagnosis, and treatment [J]. Am J Clin Dermatol, 2017, 18(4): 563-569.
[8] Tombes M, Gallucci B. The effects of hydrogen-peroxide rinses on the normal oral-mucosa [J]. Nurs Res, 1993, 42(6): 332-337.
[9] Sethi Y, Padda I, Fulton M, et al. Linezolid-induced black hairy tongue in a patient treated for idiopathic granulomatous mastitis: a case report [J]. Ann Med Surg (Lond), 2023, 85(6): 3090-3093.
[10] 郑翔,李琰华.口干的全科诊疗思路[J].中华全科医师杂志,2023,22(4): 443-448.
[11] Kakoei S, Nekouei AH, Kakooei S, et al. The effect of demographic characteristics on the relationship between smoking and dry mouth in Iran: a cross-sectional, case-control study [J]. Epidemiol Health, 2021, 43: e2021017.
[12] Barbe AG. Medication-induced xerostomia and hyposalivation in the elderly: Culprits, complications, and management [J]. Drugs Aging, 2018, 35(10): 877-885.
[13] Kullaa-Mikkonen A, Kotilainen R. The prevalence of oral carriers of Candida in patients with tongue abnormalities [J]. J Dent, 1983, 11(4): 313-317.
[14] Ren J, Zheng Y, Du H, et al. Antibiotic-induced black hairy tongue: two case reports and a review of the literature [J]. J Int Med Res, 2020, 48(10): 300060520961279.
[15] Owczarek-Drabiska JE, Radwan-Oczko M. A case of lingua villosa nigra (black hairy tongue) in a 3-month-old infant [J]. Am J Case Rep, 2020, 21: e926362.
[16] Radaic A, Kapila YL. The oralome and its dysbiosis: New insights into oral microbiome-host interactions [J]. Comput Struct Biotechnol J, 2021, 19: 1335-1360.
[17] Şenel S. An overview of physical, microbiological and immune barriers of oral mucosa [J]. Int J Mol Sci, 2021, 22(15): 7821.
[18] Bardellini E, Amadori F, Conti G, et al. Oral mucosal lesions in electronic cigarettes consumers versus former smokers [J]. Acta Odontol Scand, 2018, 76(3): 226-228.
[19] Wu J, Peters BA, Dominianni C, et al. Cigarette smoking and the oral microbiome in a large study of American adults [J]. ISME J, 2016, 10(10):2435-2446.
[20] Gurvits GE, Tan A. Black hairy tongue syndrome [J]. World J Gastroenterol, 2014, 20(31): 10845-10850.
[21] da Silva L, Kupek E, Peres KG. General health influences episodes of xerostomia: a prospective population-based study [J]. Community Dent Oral Epidemiol, 2017, 45(2): 153-159.
[22] Ralho A, Coelho A, Ribeiro M, et al. Effects of electronic cigarettes on oral cavity: A systematic review [J]. J Evid Based Dent Pract, 2019, 19(4): 101318.
[23] Song X, Greiner-Tollersrud OK, Zhou H. Oral microbiota variation: A risk factor for development and poor prognosis of esophageal cancer [J]. Dig Dis Sci, 2022, 67(8): 3543-3556.
[24] Akay BN, Sanli H, Topcuoglu P, et al. Black hairy tongue after allogeneic stem cell transplantation: an unrecognized cutaneous presentation of graft-versus-host disease [J]. Transplant Proc, 2010, 42(10): 4603-4607.
[25] Zanetti F, Zivkovic Semren T, Battey JND, et al. A literature review and framework proposal for halitosis assessment in cigarette smokers and alternative nicotine-delivery products users [J]. Front Oral Health, 2021, 2: 777442.
[26] Brookes ZLS, Bescos R, Belfield LA, et al. Current uses of chlorhexidine for management of oral disease: a narrative review [J]. J Dent, 2020, 103: 103497.
[27] Kato M, Kobayashi T, Suzuki H. Case of moxifloxacin-induced black hairy tongue [J]. Am J Case Rep, 2022, 23: e936235.
[28] 杨璐,时正媛,王淑梅.利奈唑胺致26例黑毛舌不良反应的分析[J].中国临床药理学杂志, 2023, 39(4): 568-572.
[29] Teoh L, Moses G, McCullough MJ. A review and guide to drug-associated oral adverse effects-Dental, salivary and neurosensory reactions. Part 1 [J]. J Oral Pathol Med, 2019, 48(7): 626-636.
[30] Shangguan Y, Ji Z, Guo W, et al. Oral bacteria dysbiosis in patients with linezolid-induced black hairy tongue: A case series [J]. Infect Drug Resist, 2022, 15: 5449-5454.
[31] 李旭,邱实,华泽权,等.肾移植病人术前、术后唾液免疫球蛋白变化及临床意义[J].中国现代医学杂志,2001,11(9):53,56.
[32] Coker MO, Cairo C, Garzino-Demo A. HIV-associated interactions between oral microbiota and mucosal immune cells: Knowledge gaps and future directions [J]. Front Immunol, 2021, 12: 676669.
[33] Jeong JS, Lee JY, Kim MK, et al. Black hairy tongue associated with erlotinib treatment in a patient with advanced lung cancer [J]. Ann Dermatol, 2011, 23(4): 526-528.
[34] Cecchi C, Mariniello A, Carnio S, et al. Black hairy tongue after immune checkpoint inhibitors in NSCLC: A case report and review of the literature [J]. Clin Lung Cancer, 2021, 22(6): e804-e807.
[35] Selvakumar N, Selvapandian Thamizh J, Menon V, et al. Black hairy tongue (Lingua villosa nigra) in a young male precipitated by Lithium [J]. Asian J Psychiatr, 2016, 24: 71-72.
[36] Kanodia S, Giri VP, Veerabhadrappa RS, et al. Black hairy tongue with olanzapine: A rare case report [J]. Indian J Psychiatry, 2017, 59(2): 249-250.
[37] Long S, Chen Y, Shi J, et al. Black hairy tongue associated with olanzapine use in a female dementia patient: A case report [J]. J Clin Psychopharmacol, 2022, 42(2): 211-214.
[38] Jiang L, Li K, Tan L, et al. Black hairy tongue after alprazolam intake [J]. Clin Case Rep, 2023, 11(9): e7831.
[39] Bonnet U, Ringel P. Black hairy tongue associated with lorazepam treatment of a male smoker with major depression [J]. J Clin Psychopharmacol, 2017, 37(2): 261-263.
[40] Tamam L, Annagur BB. Black hairy tongue associated with olanzapine treatment: a case report [J]. Mt Sinai J Med, 2006, 73(6): 891-894.