Research Progress on Mechanism of Ferroptosis in Salivary Gland Disease

doi:10.13701/j.cnki.kqyxyj.2025.11.001

Abstract

Abstract: Ferroptosis is a form of programmed cell death that is dependent on iron and is characterized by the peroxidation of lipids mediated by iron, as well as decreased activity of glutathione peroxidase 4 (GPX4). Salivary gland diseases include conditions such as mumps, Sjögren's syndrome, radiation-induced salivary gland injury, and both benign and malignant tumors. Previous studies have faced challenges in addressing these diseases. In recent years, researchers have increasingly focused on the role of ferroptosis in various diseases, particularly in salivary gland disease. The mechanisms behind ferroptosis closely relate to the initiation, progression, and prognosis of these conditions. The purpose of this article is to explore the intrinsic relationship between ferroptosis and salivary gland diseases, providing new insights into these conditions.

Key words: ferroptosis, salivary gland disease, lipid peroxidation, iron metabolism, research progress

YANG Rong, XU Hui. Research Progress on Mechanism of Ferroptosis in Salivary Gland Disease[J]. Journal of Oral Science Research, 2025, 41(11): 931-936.

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