Research Progress of NLRP3 in Radiation Injury of Oral and Maxillofacial Tissues

doi:10.13701/j.cnki.kqyxyj.2022.09.004

Abstract

Abstract: Radiotherapy is one of the effective measures in the treatment of head and neck tumors. Radiotherapy often leads to tissue damage such as maxillofacial skin, jaw, oral mucosa, and so on, which limits its application to a certain extent and affects the prognosis of patients. Therefore, it is necessary to find an effective method to prevent and treat maxillofacial radiation injuries. At present, studies have proved that NLRP3 is closely related to radiation-induced diseases. Inhibiting the activation mechanism of NLRP3 may effectively alleviate tissue damage. This article reviews the structure and activation mechanism of NLRP3 inflammasome and its role in oral and maxillofacial tissue damage after radiation.

Key words: NLRP3 inflammasome, radiation damage, research progress

WU Yuqi, HUANG Guilin. Research Progress of NLRP3 in Radiation Injury of Oral and Maxillofacial Tissues[J]. Journal of Oral Science Research, 2022, 38(9): 815-818.

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