Abstract: Objective: To analyze the clinical effect of pingyangmycin in the treatment of oral and maxillofacial hemangioma. Methods: Eighty-six patients with oral and maxillofacial hemangioma (43 cases of pingyangmycin group and 43 cases of cod liver oil acid sodium group) were collected from March 2008 to July 2014, meanwhile the therapeutic effect and adverse reaction were observed. Results: The therapeutic effect of pingyangmycin group was significantly better than cod liver oil acid sodium group (P<0.05), and the incidence of adverse reactions in the pingyangmycin group was obviously lower than the cod liver oil acid sodium group (P<0.05). Conclusion: Pingyangmycin has good clinical efficacy in the treatment of oral and maxillofacial hemangioma.