Abstract: Objective: To achieve in situ regeneration of enamel-like fluoridated hydroxyapatite on enamel surface under near physiological conditions. Methods: FA enamel-like structure was produced on the enamel surface of human teeth by a simple chemical method using HEDTA,CaCl₂,NaH₂PO₄·2H₂O,and NaF as the reactants under the condition of 37℃ water bath for a period of time. The physicochemical and biological properties of the enamel-like structure were studied by XRD,FTIR,SEM,XPS,MTT assay and bacterial inhibition ring test. Results: The compacted well-aligned FA crystals were produced,which could grow directly on the enamel surface. Conclusion: The synthetic structure under the condition of near physiological conditions can preliminarily mimic the shape and structure of enamel, and has the biocompatibility and certain antibacterial function.

Key words: Enamel caries, Fluorapatite, Biomimetic materials, Form controllable synthesis